This article will be permanently flagged as inappropriate and made unaccessible to everyone. Are you certain this article is inappropriate? Excessive Violence Sexual Content Political / Social
Email Address:
Article Id: WHEBN0003184819 Reproduction Date:
Lipomatosis is believed to be an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders.[1] In 1993, a genetic defect within lipomas was localized to chromosome 12q15, where the HMGIC gene encodes the high-mobility-group protein isoform I-C.[2] This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 have also been observed within.[3][4][5]
Although this condition is benign, it can sometimes be very painful depending on location of the lipomas. Some patients who are concerned with cosmetics seek removal of individual lipomas. Removal can include simple excision, endoscopic removal, or liposuction.[6]
Other entities which are accompanied by multiple lipomas include Proteus syndrome, Cowden syndrome and related disorders due to PTEN gene mutations, benign symmetric lipomatosis (Madelung disease),Dercum's Disease, familial lipodystrophy, hibernomas, epidural steroid injections with epidural lipomatosis,[7] and familial angiolipomatosis.
United States National Library of Medicine, Psychology, Medical classification, Psychiatry, Anthropology
Skin, Greek language, Integumentary system, International Statistical Classification of Diseases and Related Health Problems, Icd-10
Thoracic diaphragm, Latin, Calcium, Vagus nerve, Aorta
Cancer, Inborn errors of carbohydrate metabolism, Glucose, Metabolism, Gene
Hypertension, Urinary bladder, Rare disease, Obese, Lipomatosis
GTP-binding protein regulators, Sar1b, Inborn error of metabolism, Kras, Noonan syndrome
YouTube, Familial hypercholesterolemia, Medical Subject Headings, Inborn error of metabolism, Omim
International Statistical Classification of Diseases and Related Health Problems, Icd-10, Medical Subject Headings, Malnutrition, Vitamin E
Icd-10, Medical Subject Headings, Familial apoprotein CII deficiency, Inborn error of metabolism, International Statistical Classification of Diseases and Related Health Problems