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Substance-induced psychosis

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Title: Substance-induced psychosis  
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Subject: Phencyclidine, Alcoholic hallucinosis, Caffeine-induced sleep disorder, Barbiturate dependence, Diagnosis of schizophrenia
Collection: Psychiatric Diagnosis, Psychosis
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Substance-induced psychosis

Substance-induced psychosis
Classification and external resources
ICD-10 F10.5-F19.5
ICD-9 292.1
MeSH D011605

Substance-induced psychosis (commonly known as Toxic psychosis) is a form of substance-related disorder where psychosis can be attributed to substance use. It is a psychosis that results from the poisonous effects of chemicals or drugs, including those produced by the body itself. Various psychoactive substances have been implicated in causing or worsening psychosis in users.


  • Effects of Psychosis 1
  • Substances 2
    • ICD-10 2.1
    • Other 2.2
  • References 3

Effects of Psychosis

Psychosis manifests as disorientation and visual (and/or haptic) hallucinations.[1] It is a state in which a person's mental capacity to recognize reality, communicate, and relate to others is impaired, thus interfering with the capacity to deal with life demands. While there are many types of psychosis, substance-induced psychosis can be pinpointed to specific chemicals.[2]


Psychotic states may occur after using a variety of legal and illegal substances. Usually such states are temporary and not irreversible, with fluoroquinolone-induced psychosis being a notable exception. Drugs whose use, abuse, or withdrawal are implicated in psychosis include the following:


  • F10.5 alcohol:[3][4][5] Alcohol is a common cause of psychotic disorders or episodes, which may occur through acute intoxication, chronic alcoholism, withdrawal, exacerbation of existing disorders, or acute idiosyncratic reactions.[6] Research has shown that alcohol abuse causes an 8-fold increased risk of psychotic disorders in men and a 3 fold increased risk of psychotic disorders in women.[7][8] While the vast majority of cases are acute and resolve fairly quickly upon treatment and/or abstinence, they can occasionally become chronic and persistent.[6] Alcoholic psychosis is sometimes misdiagnosed as another mental illness such as schizophrenia.[9]
  • F12.5 cannabinoid: Some studies indicate that cannabis, especially certain strains containing large proportions of THC and low proportions of CBD,[10] may lower the threshold for psychosis, and thus help to trigger full-blown psychosis in some people.[11] Recent studies have found an increase in risk for psychosis in cannabis users.[12] It is not clear whether this is a causal link; it is possible that cannabis use only increases the risk of psychosis in people already predisposed to it.
  • F14.5 cocaine[23]
  • F16.5 hallucinogens (LSD and others)

The code F11.5 is reserved for opioid-induced psychosis, and F17.5 is reserved for tobacco-induced psychosis, but neither substance is traditionally associated with the induction of psychosis.

The code F15.5 also includes caffeine-induced psychosis, despite not being specifically listed in the DSM-IV. However, there is evidence that caffeine, in extreme acute doses or when severely abused for long periods of time, may induce psychosis.[25][26]


  • Synthetic research chemicals used recreationally, including:
    • JWH-018 and some other synthetic cannabinoids, or mixtures containing them (e.g. "Spice", "Kronic", "MNG" or "Mr. Nice Guy", "Relaxinol", etc.).[54] Various "JWH-XXX" compounds in "Spice" or "Incense" have also been found and have been found to cause psychosis in some people.[55][56]
    • Mephedrone and related amphetamine-like drugs sold as "bath salts" or "plant food".[57]


  1. ^ The Dilemma of the Toxic Psychosis: Differential Diagnosis and the PCP Psychosis | Pitts, Ferris N, JR, MD; Allen, Robert E, MDView Profile; Aniline, Orm, MD, PHD; Burgoyne, Rodney W, MD. Psychiatric Annals12.8 (Aug 1982): 762-764,766-768
  2. ^
  3. ^ Larson, Michael (2006-03-30). "Alcohol-Related Psychosis". eMedicine. WebMD. Retrieved September 27, 2006. 
  4. ^ Soyka, Michael (March 1990). "Psychopathological characteristics in alcohol hallucinosis and paranoid schizophrenia".  
  5. ^ Gossman, William (November 19, 2005). "Delirium Tremens". eMedicine. WebMD. Retrieved October 16, 2006. 
  6. ^ a b Alcohol-Related Psychosis
  7. ^ Tien AY, Anthony JC (August 1990). "Epidemiological analysis of alcohol and drug use as risk factors for psychotic experiences". J. Nerv. Ment. Dis. 178 (8): 473–80.  
  8. ^ Cargiulo T (March 2007). "Understanding the health impact of alcohol dependence". Am J Health Syst Pharm 64 (5 Suppl 3): S5–11.  
  9. ^ Schuckit MA (November 1983). "Alcoholism and other psychiatric disorders". Hosp Community Psychiatry 34 (11): 1022–7.  
  10. ^ THC and Psychosis from Neuropsychopharmacology 35, 764–774, dated 1 February 2010.
  11. ^ Degenhardt L (January 2003). "The link between cannabis use and psychosis: furthering the debate". Psychological Medicine 33 (1): 3–6.  
  12. ^ Moore TH, Zammit S, Lingford-Hughes A, et al. (July 2007). "Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review". Lancet 370 (9584): 319–28.  
  13. ^ de Paola L, Mäder MJ, Germiniani FM, et al. (June 2004). "Bizarre behavior during intracarotid sodium amytal testing (Wada test): are they predictable?". Arquivos De Neuro-psiquiatria 62 (2B): 444–8.  
  14. ^ Sarrecchia C, Sordillo P, Conte G, Rocchi G (1998). "[Barbiturate withdrawal syndrome: a case associated with the abuse of a headache medication]". Annali Italiani Di Medicina Interna (in Italian) 13 (4): 237–9.  
  15. ^ White MC, Silverman JJ, Harbison JW (February 1982). "Psychosis associated with clonazepam therapy for blepharospasm". The Journal of Nervous and Mental Disease 170 (2): 117–9.  
  16. ^ Jaffe R, Gibson E (June 1986). "Clonazepam withdrawal psychosis". Journal of Clinical Psychopharmacology 6 (3): 193.  
  17. ^ Hallberg RJ, Lessler K, Kane FJ (August 1964). "Korsakoff-Like Psychosis Associated With Benzodiazepine Overdosage". The American Journal of Psychiatry 121: 188–9.  
  18. ^ Hall RC, Zisook S (1981). "Paradoxical reactions to benzodiazepines". British Journal of Clinical Pharmacology 11 (Suppl 1): 99S–104S.  
  19. ^ Lader M, Morton S. Benzodiazepine Problems. British Journal of Addiction 1991; 86: 823-828
  20. ^ Benzodiazepines: Paradoxical Reactions & Long-Term Side-Effects
  21. ^ Hansson O, Tonnby B. [Serious Psychological Symptoms Caused by Clonazepam.] Läkartidningen 1976; 73: 1210-1211.
  22. ^ Pétursson H (November 1994). "The benzodiazepine withdrawal syndrome". Addiction 89 (11): 1455–9.  
  23. ^ Brady, K. T.; R. B. Lydiard; R. Malcolm; J. C. Ballenger (December 1991). "Cocaine-induced psychosis". Journal of Clinical Psychiatry 52 (12): 509–512.  
  24. ^ a b c Diaz, Jaime. How Drugs Influence Behavior. Englewood Cliffs: Prentice Hall, 1996.
  25. ^ Hedges DW, Woon FL, Hoopes SP (March 2009). "Caffeine-induced psychosis". CNS Spectrums 14 (3): 127–9.  
  26. ^ Cerimele JM, Stern AP, Jutras-Aswad D (March 2010). "Psychosis following excessive ingestion of energy drinks in a patient with schizophrenia". The American Journal of Psychiatry 167 (3): 353.  
  27. ^ Cohen JS (December 2001). "Peripheral Neuropathy Associated with Fluoroquinolones" (PDF). Ann Pharmacother 35 (12): 1540–7.  
  28. ^ Adams M, Tavakoli H (2006). "Gatifloxacin-induced hallucinations in a 19-year-old man". Psychosomatics 47 (4): 360.  
  29. ^ Mulhall JP, Bergmann LS (July 1995). "Ciprofloxacin-induced acute psychosis". Urology 46 (1): 102–3.  
  30. ^ Reeves RR (1992). "Ciprofloxacin-induced psychosis". Ann Pharmacother 26 (7–8): 930–1.  
  31. ^ Yasuda H, Yoshida A, Masuda Y, Fukayama M, Kita Y, Inamatsu T (March 1999). "[Levofloxacin-induced neurological adverse effects such as convulsion, involuntary movement (tremor, myoclonus and chorea like), visual hallucination in two elderly patients]". Nippon Ronen Igakkai Zasshi (in Japanese) 36 (3): 213–7.  
  32. ^ Azar S, Ramjiani A, Van Gerpen JA (April 2005). "Ciprofloxacin-induced chorea". Mov. Disord. 20 (4): 513–4; author reply 514.  
  33. ^ Kukushkin ML, Igonkina SI, Guskova TA (April 2004). "Mechanisms of pefloxacin-induced pain". Bull. Exp. Biol. Med. 137 (4): 336–8.  
  34. ^ Christie MJ, Wong K, Ting RH, Tam PY, Sikaneta TG (May 2005). "Generalized seizure and toxic epidermal necrolysis following levofloxacin exposure". Ann Pharmacother 39 (5): 953–5.  
  35. ^ Marsepoil T, Petithory J, Faucher JM, Ho P, Viriot E, Benaiche F (1993). "[Encephalopathy and memory disorders during treatments with mefloquine]". Rev Med Interne (in French) 14 (8): 788–91.  
  36. ^ Phillips-Howard PA, ter Kuile FO (June 1995). "CNS adverse events associated with antimalarial agents. Fact or fiction?". Drug Saf 12 (6): 370–83.  
  37. ^ Price, L. H.; Lebel, J. (2000). "Dextromethorphan-Induced Psychosis". American Journal of Psychiatry 157 (2): 304.  
  38. ^ Lachover, L. (2007). "Deciphering a Psychosis: A Case of Dextromethorphan-Induced Symptoms". Primary Psychiatry 14 (1): 70–72. 
  39. ^ Sexton, J. D.; Pronchik, D. J. (1997). "Diphenhydramine-induced psychosis with therapeutic doses". The American Journal of Emergency Medicine 15 (5): 548–549.  
  40. ^ Lang, K.; Sigusch, H.; Müller, S. (1995). "Anticholinergisches Syndrom mit halluzinatorischer Psychose nach Diphenhydramin-Intoxikation" [An anticholinergic syndrome with hallucinatory psychosis after diphenhydramine poisoning].  
  41. ^ Schreiber, W.; Pauls, A. M.; Krieg, J. C. (1988). "Toxische Psychose als Akutmanifestation der Diphenhydraminvergiftung" [Toxic psychosis as an acute manifestation of diphenhydramine poisoning].  
  42. ^ Timnak, C.; Gleason, O. (2004). "Promethazine-Induced Psychosis in a 16-Year-Old Girl". Psychosomatics 45 (1): 89–90.  
  43. ^ Gunn, V. L.; Taha, S. H.; Liebelt, E. L.; Serwint, J. R. (2001). "Toxicity of Over-the-Counter Cough and Cold Medications". Pediatrics 108 (3): e52.  
  44. ^ Hall, R. C.; Popkin, M. K.; Stickney, S. K.; Gardner, E. R. (1979). "Presentation of the steroid psychoses". The Journal of Nervous and Mental Disease 167 (4): 229–236.  
  45. ^ Hull, P. R., & D’Arcy, C. (2003). Isotretinoin Use and Subsequent Depression and Suicide: Presenting the Evidence. American Journal Of Clinical Dermatology, 4(7), 493-505.
  46. ^ Bergman, K. R.; Pearson, C.; Waltz, G. W.; Evans R. III (1980). "Atropine-induced psychosis. An unusual complication of therapy with inhaled atropine sulfate". Chest 78 (6): 891–893.  
  47. ^ Varghese, S.; Vettath, N.; Iyer, K.; Puliyel, J. M.; Puliyel, M. M. (1990). "Ocular atropine induced psychosis--is there a direct access route to the brain?". Journal of the Association of Physicians of India 38 (6): 444–445.  
  48. ^ Barak, Segev; Weiner, I. (2006). "Scopolamine Induces Disruption of Latent Inhibition Which is Prevented by Antipsychotic Drugs and an Acetylcholinesterase Inhibitor". Neuropsychopharmacology 32 (5): 989–999.  
  49. ^ Gaylord Ellison, The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias, Brain Research Reviews, Volume 20, Issue 2, February 1995, Pages 250-267, ISSN 0165-0173, (
  50. ^ Carey, R. J.; Pinheiro-Carrera, M.; Dai, H.; Tomaz, C.; Huston, J. P. (1995). "l-DOPA and psychosis: Evidence for l-DOPA-induced increases in prefrontal cortex dopamine and in serum corticosterone". Biological Psychiatry 38 (10): 669–676.  
  51. ^ Ettinger, A. B. (2006). "Psychotropic effects of antiepileptic drugs". Neurology 67 (11): 1916–1925.  
  52. ^ 'Ecstasy' Psychosis and Flashbacks F.J. CREIGHTON,D. L. BLACK and C. E. HYDE
  53. ^ Substance-induced psychotic disorder
  54. ^ Spice users risk psychosis, doctor says By Gidget Fuentes - Staff writer Accessed 06-25-2011
  55. ^ Every-Palmer S. Warning: legal synthetic cannabinoid-receptor agonists such as JWH-018 may precipitate psychosis in vulnerable individuals. Addiction. 2010 Oct;105(10):1859-60. doi:10.1111/j.1360-0443.2010.03119.x PMID 20840203
  56. ^ Müller H et al The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes. Schizophr Res. 2010 May;118(1-3):309-10. PMID 20056392
  57. ^ Bath Salt Addiction, Accessed 06-25-2011
  58. ^ Kurzbaum, Alberto; Claudia Simsolo, Ludmilla Kvasha and Arnon Blum (July 2001). "Toxic Delirium due to Datura Stramonium" (PDF). Israel Medical Association Journal 3 (7): 538–539.  
  59. ^ Przekop, Peter; Timothy Lee (July 2009). Use"Salvia Divinorum"Persistent Psychosis Associated With . American Journal of Psychiatry 166 (832): 832.  
  60. ^ Tarsh, M.J. (1979). "Schizophreniform Psychosis caused by Sniffing Toluene" (PDF). Journal of the Society for Occupational Medicine 1979 (29): 131–133.  
  61. ^ Rao, Naren P.; Arun Gupta; K. Sreejayan; Prabhat K. Chand; Vivek Benegal; Pratima Murthy (2009). "Toluene associated schizophrenia-like psychosis". Indian Journal of Psychiatry 51 (4): 329–330.  
  62. ^ Jung IK, Lee HJ, Cho BH (December 2004). "Persistent psychotic disorder in an adolescent with a past history of butane gas dependence". European Psychiatry 19 (8): 519–20.  
  63. ^ Hernandez-Avila, Carlos A.; Hector A. Ortega-Soto; Antonio Jasso; Cecilia A. Hasfura-Buenaga; Henry R. Kranzler (1998). "Treatment of Inhalant-Induced Psychotic Disorder With Carbamazepine Versus Haloperidol". Psychiatric Services 49 (6): 812–815.  
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