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Calcium ATPase

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Title: Calcium ATPase  
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Subject: P-type ATPase, ATPase, Hydrogen potassium ATPase, Transporter Classification Database, Wilson disease protein
Collection: Transmembrane Proteins, Transport Proteins
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Calcium ATPase

Ca2+ ATPase is a form of P-ATPase that transfers calcium after a muscle has contracted. The calcium ATPase are:[1]


  • Plasma membrane Ca2+ ATPase (PMCA) 1
  • Sarcoplasmic reticulum Ca2+ ATPase (SERCA) 2
  • See also 3
  • References 4
  • External links 5

Plasma membrane Ca2+ ATPase (PMCA)

Rendered image of the Ca2+ pump

The plasma membrane Ca2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells that serves to remove calcium (Ca2+) from the cell. It is vital for regulating the amount of Ca2+ within cells.[2] In fact, the PMCA is involved in removing Ca2+ from all eukaryotic cells.[3] There is a very large transmembrane electrochemical gradient of Ca2+ driving the entry of the ion into cells, yet it is very important for cells to maintain low concentrations of Ca2+ for proper cell signalling; thus it is necessary for the cell to employ ion pumps to remove the Ca2+.[4] The PMCA and the sodium calcium exchanger (NCX) are together the main regulators of intracellular Ca2+ concentrations.[3] Since it transports Ca2+ into the extracellular space, the PMCA is also an important regulator of the calcium concentration in the extracellular space.[5]

The PMCA belongs to a family of P-type primary ion transport ATPases that form an aspartyl phosphate intermediate.[3]

The PMCA is expressed in a variety of tissues, including the brain.[6]

Sarcoplasmic reticulum Ca2+ ATPase (SERCA)

SERCA resides in the sarcoplasmic reticulum (SR) within muscle cells. It is a Ca2+ ATPase that transfers Ca2+ from the cytosol of the cell to the lumen of the SR at the expense of ATP hydrolysis during muscle relaxation.

See also


  1. ^
  2. ^ Jensen, TP; Buckby LE; Empson RM (2004). "Expression of plasma membrane Ca2+ ATPase family members and associated synaptic proteins in acute and cultured organotypic hippocampal slices from rat". Developmental Brain Research 152 (2): 129–136.  
  3. ^ a b c Strehler, EE; Zacharias DA (2001). "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps". Physiological Reviews (American Physiological Society) 81 (1): 21–50.  
  4. ^ Carafoli, E (1991). "Calcium pump of the plasma membrane". Physiological Reviews 71 (1): 129–153.  
  5. ^ Talarico Jr, EF; Kennedy BG; Marfurt CF; Loeffler KU; Mangini NJ (2005). "Expression and immunolocalization of plasma membrane calcium ATPase isoforms in human corneal epithelium". Molecular Vision 11: 169–178.  
  6. ^ Jensen, TP; Filoteo A; Knopfel T; Empson RM (2006). ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3"2+"Pre-synaptic plasma membrane Ca. Journal of Physiology 579 (Pt 1): Published online ahead of print.  

External links

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