World Library  
Flag as Inappropriate
Email this Article

D-amino acid oxidase

Article Id: WHEBN0006430965
Reproduction Date:

Title: D-amino acid oxidase  
Author: World Heritage Encyclopedia
Language: English
Subject: EC 1.4.3, FAD dependent oxidoreductase family, Eudysmic ratio, DAO, Flavoprotein
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

D-amino acid oxidase

D-amino-acid oxidase
3D structure of DAAO from yeast (monomer)
Identifiers
EC number 1.4.3.3
CAS number 9000-88-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
D-amino-acid oxidase
Identifiers
Symbol DAO (DAAO)
Entrez 1610
HUGO 2671
OMIM 124050
RefSeq NM_001917
UniProt P14920
Other data
EC number 1.4.3.3
Locus Chr. 12 q24

D-amino acid oxidase (DAAO; also DAO, OXDA, DAMOX) is a peroxisomal enzyme containing FAD as cofactor that is expressed in a wide range of species from yeasts to human.[1] It is not present in plants or in bacteria which instead use D-amino acid dehydrogenase. Its function is to oxidize D-amino acids to the corresponding imino acids, producing ammonia and hydrogen peroxide.

This enzyme belongs to the FAD dependent oxidoreductase family, and acts on the CH-NH2 group of D-amino acid donors with oxygen as acceptor. The enzyme is most active toward neutral D-amino acids, and not active toward acidic D-amino acids.

Recently, mammalian D-amino acid oxidase has been connected to the brain D-serine metabolism and to the regulation of the glutamatergic neurotransmission. In a postmortem study, the activity of DAAO was found to be two-fold higher in schizophrenia.[2]

DAAO is a candidate susceptibility gene[3] and together with G72 may play a role in the glutamatergic mechanisms of schizophrenia.[4] Risperidone and sodium benzoate are inhibitors of DAAO.

DAAO is used as a biocatalyst in several biotechnological applications, such as the oxidation of cephalosporin C, the deracemition of racemic D-amino acid solutions and as the biological component in several biosensors for the determination of the content in D-amino acids of biological fluids.

This protein may use the morpheein model of allosteric regulation. [5]


See also

External links

  • D-Amino-Acid Oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
  • http://www.calzyme.com/commerce/catalog/spcategory.jsp?category_id=1043

References

  1. ^
  2. ^
  3. ^ Gene Overview of All Published Schizophrenia-Association Studies for DAAO - SZGene database.
  4. ^
  5. ^


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.