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Branched chain aminotransferase

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Title: Branched chain aminotransferase  
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Branched chain aminotransferase

branched chain aminotransferase
"RCSB Protein Data Bank - Structure Summary for 3DTF - Structural analysis of mycobacterial branched chain aminotransferase- implications for inhibitor design". 
Identifiers
Symbol BCAT
Alt. symbols BCT
Entrez 587
HUGO 977
OMIM 113530
RefSeq NM_001190
UniProt O15382
Other data
EC number 2.6.1.42
Locus Chr. 19 q13

Branched chain aminotransferase is an aminotransferase enzyme which acts upon branched-chain amino acids. It uses largely α-ketoglutarate in forming branched chain α-keto acids and glutamate.

The structure to the right of branched chain aminotransferase was found using X-ray diffraction with a resolution of 2.20 Å. The branched chain aminotransferase found in this image was isolated from mycobacteria. This protein is made up of two identical polypeptide chains. The protein is a total of 372 residues(1). As can be seen in the image, the protein is made of helices and beta sheets.

The biological function of branched chain aminotransferases (BCAT) is to catalyse the synthesis or degradation of the branched chain amino acids leucine, isoleucine, and valine(2). In humans, branched chain amino acids are essential and are degraded by BCATs.

  • (1) "RCSB Protein Data Bank - Structure Summary for 3DTF - Structural analysis of mycobacterial branched chain aminotransferase- implications for inhibitor design". 
  • (2) "Structure and function of branched chain aminotran... [Prog Nucleic Acid Res Mol Biol. 2001] - PubMed result". 

External links

  • branched-chain-amino-acid transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
  • "RCSB Protein Data Bank - Structure Summary for 3DTF - Structural analysis of mycobacterial branched chain aminotransferase- implications for inhibitor design". 
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