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Lymphotoxin alpha

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Title: Lymphotoxin alpha  
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Subject: Leprosy, Proinflammatory cytokine, Interleukin 5, Interferon alfa 2b, Fever
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Lymphotoxin alpha

Lymphotoxin alpha

PDB rendering based on 1tnr.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; LT; TNFB; TNFSF1
External IDs ChEMBL: GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Lymphotoxin-alpha (LT-alpha) is a protein that in humans is encoded by the LTA gene.[1][2]


Lymphotoxin alpha, a member of the [3]

In LTα knockout mice, all Peyer's patches and lymph nodes will fail to develop indicating LTα's importance in immunological development.[4]


Lymphotoxin alpha has been shown to interact with LTB.[5][6][7]

See also


  1. ^ Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, Pennica D, Goeddel DV, Gray PW (November 1985). "Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization". Nucleic Acids Res 13 (17): 6361–6373.  
  2. ^ Aggarwal BB, Eessalu TE, Hass PE (February 1986). "Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon". Nature 318 (6047): 665–7.  
  3. ^ "Entrez Gene: LTA lymphotoxin alpha (TNF superfamily, member 1)". 
  4. ^ Akirav, Eitan; Liao, Shan; Ruddle, Nancy (2008). "Chapter 2: Lymphoid Tissues and Organs". In Paul, William. Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 27–55.  
  5. ^ Williams-Abbott, L; Walter B N; Cheung T C; Goh C R; Porter A G; Ware C F (August 1997). "The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand". J. Biol. Chem. (UNITED STATES) 272 (31): 19451–19456.  
  6. ^ Browning, J L; Sizing I D, Lawton P, Bourdon P R, Rennert P D, Majeau G R, Ambrose C M, Hession C, Miatkowski K, Griffiths D A, Ngam-ek A, Meier W, Benjamin C D, Hochman P S (October 1997). "Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes". J. Immunol. (UNITED STATES) 159 (7): 3288–98.  
  7. ^ Browning, J L; Dougas I; Ngam-ek A; Bourdon P R; Ehrenfels B N; Miatkowski K; Zafari M; Yampaglia A M; Lawton P; Meier W (January 1995). "Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors". J. Immunol. (UNITED STATES) 154 (1): 33–46.  

Further reading

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