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Title: Cd109  
Author: World Heritage Encyclopedia
Language: English
Subject: CD1A, CD153, CD320, IGSF2, NKG2
Collection: Clusters of Differentiation
Publisher: World Heritage Encyclopedia


CD109 molecule
Symbols  ; CPAMD7; p180; r150
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

CD109 (Cluster of Differentiation 109) is a human gene.[1] CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system, implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM][1]


  • See also 1
  • References 2
  • Further reading 3
  • External links 4

See also


  1. ^ a b "Entrez Gene: CD109 CD109 molecule". 

Further reading

  • Lucas GF, Metcalfe P (2000). "Platelet and granulocyte glycoprotein polymorphisms.". Transfusion medicine (Oxford, England) 10 (3): 157–74.  
  • Sutherland DR, Yeo E, Ryan A, et al. (1991). "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets.". Blood 77 (1): 84–93.  
  • Kelton JG, Smith JW, Horsewood P, et al. (1990). "Gova/b alloantigen system on human platelets.". Blood 75 (11): 2172–6.  
  • Lin M, Sutherland DR, Horsfall W, et al. (2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins.". Blood 99 (5): 1683–91.  
  • Schuh AC, Watkins NA, Nguyen Q, et al. (2002). "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens.". Blood 99 (5): 1692–8.  
  • Giesert C, Marxer A, Sutherland DR, et al. (2003). "Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets.". Ann. N. Y. Acad. Sci. 996: 227–30.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5.  
  • Solomon KR, Sharma P, Chan M, et al. (2004). "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family.". Gene 327 (2): 171–83.  
  • Zhang JM, Hashimoto M, Kawai K, et al. (2005). "CD109 expression in squamous cell carcinoma of the uterine cervix.". Pathol. Int. 55 (4): 165–9.  
  • Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.". Mol. Cell Proteomics 5 (2): 226–33.  
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80.  
  • Finnson KW, Tam BY, Liu K, et al. (2006). "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes". FASEB J. 20 (9): 1525–7.  
  • Sjöblom T, Jones S, Wood LD, et al. (2006). "The consensus coding sequences of human breast and colorectal cancers". Science 314 (5797): 268–74.  
  • Hasegawa M, Hagiwara S, Sato T, et al. (2007). "CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells". Pathol. Int. 57 (5): 245–50.  

External links

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