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Outline of immunology

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Title: Outline of immunology  
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Outline of immunology

The following outline is provided as an overview of and topical guide to immunology:

[1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.

Essence of immunology

Main article: Immunology

Branches of immunology

History of immunology

Main article: History of immunology

General immunological concepts

  • Immunity against:

Components of the immune system

  Adaptive immune system

  • Kinds of Antibodies
  • Classification
  • Functions
  • Regions

  Innate immune system

  • Positive
  • Negative

Organs of the immune system

  Primary Lymphoid Organs

  Secondary Lymphoid Organs

Cells of the immune system

  Myeloid Cells

  Lymphoid Cells


(Non-hematopoietic cells with immune functions)


Molecules of the Immune System

Immune receptors

   Antigen receptors

  • Stimulatory
  • Inhibitory
  • Accessory molecule (CD79)
  • Co-receptors
  • Accessory molecules

   Pattern recognition receptors (PRRs)

  • Dectin 1 subfamily
  • DCIR subfamily
  • Class A - Trimers
  • Class B - Two transmembrane domains
  • Others
  • NLRA (A for acidic transactivating domain)
  • NLRX

   Complement receptors

   Fc receptors

  • Secreted Fc receptors

   Cytokine receptors

  • Others
  • EPOR (Erythropoietin receptor) - Homodimer
  • G-CSFR (CD114) - Homodimer upon ligand binding
  • MPL (CD110, Thrombopoietin receptor) - Homodimer upon ligand binding
  • GHR (Growth hormone receptor) - Homodimer upon ligand binding
  • PRLR (Prolactin receptor)
  • Interleukin receptors
  • CX3CR1 (Fractalkine receptor)

   Natural killer cell receptors

  • Activating KIRs
  • Two domains, long cytoplasmic tail
  • Two domains, short cytoplasmic tail
  • Three domains, long cytoplasmic tail
  • Three domains, short cytoplasmic tail




  • CX3CL1 (Fractalkine, Neurotactin)


Complement proteins

  • Early stage (divided by pathway)
  • Middle stage
  • Late stage
  • Complement pathway inhibitors

Antimicrobial peptides

Transcription factors

  • T-bet - TH1 differentiation
  • GATA3 - TH2 differentiation
  • RORγT - TH17 differentiation
  • BCL6 - TFH differentiation
  • FoxP3 - Treg differentiation

Signaling pathways

Cell adhesion molecules (CAMs)

  • Alpha subunits
  • Beta subunits
  • Dimers
  • Cytoadhesin receptor
  • Leukocyte-adhesion receptor:
  • Very late antigen receptor:
  • Others


  • CD28 - Expressed by T Cells
  • CD278 (ICOS) - Homodimer, expressed by T Cells
  • CTLA-4 (CD152)
  • PD-1 (CD279)

Immune system disorders

Hypersensitivity and Allergy

  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • GVHD (Graft-versus-host disease)
  • Unknown/Multiple types
  • Foreign
  • Autoimmune


Cancers of the immune system

Myeloid diseases

Inflammatory diseases

Immunoproliferative immunoglobulin disorders

Lymphatic organ disease

Immunologic techniques and tests

Immunology and Health


Main article: List of immunologists

Immunology lists


  1. ^ Janeway's Immunobiology textbook Searchable free online version at the National Center for Biotechnology Information
  2. ^
  3. ^
  4. ^

External links

  • BMC: Immunology- BioMed Central:Immunology is an open access journal publishing original peer-reviewed research articles.
  • Nature Reviews Immunology ( journal home)
  • Janeway's Immunobiology textbook Searchable free online version at the National Center for Biotechnology Information
  • Overview at Medical College of Georgia
  • MUGEN NoE murine models for immunological disease
  • Transplantation Immunology Interesting web site made by the faculty of medicine of the University of Geneva dealing with the immunological issues linked with the transplantation of materials genetically different between donor and recipient (hematopoietical stem cells, organs or the transfusion of blood).
  • Online lectures in immunology University of South Carolina
  • BRT-Burleson Research Technologies Tests the effects of pharmaceuticals in the developmental stage on the immune system.
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