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Immunosignature

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Title: Immunosignature  
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Subject: Immune system, Index of immunology articles
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Immunosignature

Immunosignaturing is a medical diagnostic test which uses arrays of random-sequence peptides to associate antibodies in a blood sample with a disease. Patent: "Compound Arrays for Sample Profiling", WO 2,010,148,365, inventor(s): Johnston, Stephen A; Stafford, Phillip.

References

  • "2007 GELSS Symposium Abstracts".  
  • Legutki JB, Magee DM, Stafford P, Johnston SA. "A general method for characterization of humoral immunity induced by a vaccine or infection". doi: 10.1016/j.vaccine.2010.04.061 Vaccine, 2010.
  • Brown P, Stafford P, Johnston SA, Dinu Valentin: "Statistical Methods for Analyzing Immunosignatures". BMC Bioinformatics, 12:349, doi:10.1186/1471-2105-12-349, 2011.
  • Restrepo L, Stafford P, Magee DM, Johnston SA. "Application of immunosignatures to the assessment of Alzheimer's disease". Annals of Neurology doi:10.1002/ana.22405. 2011.
  • Halperin RF, Stafford P, Johnston SA. "Exploring antibody recognition of sequence space through random-sequence microarrays". Molecular and Cellular Proteomics doi:10.1074/mcp.M110.000786. 2011.
  • Stafford P, Johnston SA. "Microarray Technology Displays the Complexities of the Humoral Immune Response". Expert Reviews in Molecular Diagnostics 11(1):5-8. 2011
  • Halperin, RF. "Characterization and Analysis of a Novel Platform for Profiling the Antibody Response". Doctoral dissertation at Arizona State University, Proquest Publication No. 3482763. 2011.
  • Halperin RF, Stafford P, Emery JS, Navalkar KA, Johnston SA: "GuiTope: An Application for Mapping Random-Sequence Peptides to Protein Sequences", BMC Bioinformaticsˆ, 13:1, doi:10.1186/1471-2105-13-1. 2012.
  • Kukreja M, Johnston SA, Stafford P: "Immunosignaturing Microarrays Distinguish Antibody Profiles of Related Pancreatic Diseases", Journal of Proteomics and Bioinformatics, doi:10.4172/jpb.S6-001. 2012.
  • Stafford P, Halperin R, Legutki JB, Magee DM, Galgiani J, Johnston SA: "Physical Characterization of the ‘Immunosignaturing Effect", doi:10.1074/mcp.M111.011593, Molecular and Cellular Proteomics. 2012.
  • Kukreja M, Johnston SA, Stafford P: "Comparative Study of Classification Algorithms for Immunosignaturing Data", doi:10.1186/1471-2105-13-139, BMC Bioinformatics. 2012.
  • Hughes A, Cichacz Z, Scheck A, Coons SW, Johnston SA, Stafford P: "Immunosiganturing Can Detect Products from Molecular Markers in Brain Cancer", doi:10.1371/journal.pone.0040201, PLoS ONE, 2012.
  • Chase BA, Johnston SA and Legutki JB. "Evaluation of Biological Sample Preparation for Immunosignature-Based Diagnostics", doi:10.1128/CVI.05667-11, Clinical and Vaccine Immunology, 2012.
  • Kroening K, Johnston SA, Legutki JB. "Autoreactive antibodies raised by self derived de novo peptides can identify unrelated antigens on protein microarrays", doi:10.1016/j.yexmp.2012.03.002, Experimental and Molecular Pathology, 2012.
  • Restrepo L, Stafford P, Johnston SA. "Feasibility of an early Alzheimer's disease immunosignature diagnostic test", doi:10.1016/j.jneuroim.2012.09.014, Journal of Neuroimmunology, 2012.
  • Kukreja M. Analysis of "Immunosignaturing Case Studies". Doctoral dissertation at Arizona State University, Proquest Publication No. 3544231. 2012.
  • Restrepo JL. "Immunosignature of Alzheimer's Disease". Doctoral dissertation at Arizona State University, Proquest Publication No. 3487428. 2012.
  • Sykes K., Legutki JB, Stratford P. "Immunosignaturing: a critical review", doi: 10.1016/j.tibtech.2012.10.012, Cell Press, 2012.
  • Johnston SA "Healthcare by Mail", http://www.zocalopublicsquare.org/2011/09/12/dear-john-you-have-psoriasis/ideas/nexus/
  • Legutki JB, Johnston SA: "Immunosignatures can predict vaccine efficacy", Proceedings of the National Academy of Sciences doi:10.1073/pnas.130939011, PNAS, 2013.
  • Navalkar KA, Johnston SA, Woodbury N, Galgiani J, Magee DM, Chicacz Z, Stafford P. "Application of Immunosigantures to Diagnosis of Valley Fever", doi:10.1128/CVI.00228-14, Clinical and Vaccine Immunology, 2014.
  • Williams S, Stafford P, Hoffman SA. "Diagnosis and Early Detection of CNS-SLE in MRL/lpr Mice Using Peptide Microarrays", doi:10.1186/1471-2172-15-23, BMC Immunology, 2014.
  • Stafford P, Cichacz Z, Woodbury N, Johnston SA. "Immunosignature System for Diagnosis of Cancer", doi: 10.1073/pnas.1409432111, PNAS, 2014.
  • Legutki JB, Zhao ZG, Greving M, Woodbury N, Johnston SA, Stafford P. "Scalable High-Density Peptide Arrays for Comprehensive Health Monitoring", doi:10.1038/ncomms5785, Nature Communications, 2014.

Commercialization

HealthTell is an early stage Life Sciences company that utilizes an ImmunoSignature Technology for accurate and timely detection and monitoring of more than 30 progressive diseases. Based on robust, proprietary technology, the company is developing the first and only diagnostic platform capable of assessing an individual’s immune system response to specific diseases. This disruptive technology enables physicians to detect the presence or absence of a disease in its earliest stage, improving patient outcomes and reducing healthcare expenditures. Applicable to a broad range of therapeutic areas, HealthTell is empowering physicians and patients to proactively manage one’s health and make more informed decisions. For more information, please visit: http://www.healthtell.com/


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