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Pitrazepin

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Title: Pitrazepin  
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Subject: Nipecotic acid, Sinomenine, Quisqualamine, Isonipecotic acid, Thiocolchicoside
Collection: Convulsants, Gaba Antagonists, Gabaa Receptor Antagonists, Glycine Receptor Antagonists, Piperazines, Triazoles
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Pitrazepin

Pitrazepin
Systematic (IUPAC) name
3-(piperazin-1-yl)-9H-dibenzo[c,f][1,2,4]triazolo[4,3-a]azepine
Clinical data
Pregnancy cat.
  • ?
Legal status
  • Uncontrolled
Routes ?
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
Chemical data
Formula C19H19N5 
Mol. mass 317.39 g/mol

Pitrazepin is a competitive GABAA and glycine receptor antagonist.[1][2][3] It has been used to study insect and snail nervous systems in scientific research.[4][5][6][7][8][9]

See also

References

  1. ^ Gähwiler BH, Maurer R, Wüthrich HJ (April 1984). "Pitrazepin, a novel GABAA antagonist". Neuroscience Letters 45 (3): 311–6.  
  2. ^ Braestrup C, Nielsen M (November 1985). "Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors". European Journal of Pharmacology 118 (1-2): 115–21.  
  3. ^ Curtis DR, Gynther BD (November 1986). "Pitrazepin: a central glycine and GABA antagonist". European Journal of Pharmacology 131 (2-3): 311–3.  
  4. ^ Anthony NM, Harrison JB, Sattelle DB (1993). "GABA receptor molecules of insects". Exs 63: 172–209.  
  5. ^ Sattelle DB, Pinnock RD, Wafford KA, David JA (January 1988). "GABA receptors on the cell-body membrane of an identified insect motor neuron".  
  6. ^ Murphy VF, Wann KT (November 1988). "The action of GABA receptor agonists and antagonists on muscle membrane conductance in Schistocerca gregaria".  
  7. ^ Zhang W, Han XY, Wong SM, Takeuchi H (January 1997). "Pharmacologic characteristics of excitatory gamma-amino-butyric acid (GABA) receptors in a snail neuron". General Pharmacology 28 (1): 45–53.  
  8. ^ Kim KH, Takeuchi H (June 1990). "Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones". European Journal of Pharmacology 182 (1): 49–62.  
  9. ^ Takeuchi H (September 1992). "Sensitivities of Achatina giant neurones to putative amino acid neurotransmitters". Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology 103 (1): 1–12.  



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