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Oculomucocutaneous syndrome

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Title: Oculomucocutaneous syndrome  
Author: World Heritage Encyclopedia
Language: English
Subject: Pharmacology
Publisher: World Heritage Encyclopedia

Oculomucocutaneous syndrome

Oculomucocutaneous syndrome is characterized by keratoconjunctivitis sicca and by scarring, fibrosis, metaplasia, and shrinkage of the conjunctiva.[1] It is a drug side effect observed in practolol and eperisone. It is speculated that antibodies against drug metabolites cause the syndrome.[2]


  1. ^ Wright, P (Mar 15, 1975). "Untoward effects associated with practolol administration: oculomucocutaneous syndrome.". British Medical Journal 1 (5958): 595–8.  
  2. ^ Amos, HE; Lake, BG; Artis, J (Feb 18, 1978). "Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome.". British Medical Journal 1 (6110): 402–4.  

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