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17-Phenylandrostenol

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Title: 17-Phenylandrostenol  
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Subject: N4-Chloroacetylcytosine arabinoside, GABA transaminase inhibitor, (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid, Gabaculine, GABA receptor antagonist
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17-Phenylandrostenol

17-Phenylandrostenol
Systematic (IUPAC) name
(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-phenyl- 2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Clinical data
Legal status
?
Identifiers
CAS number  N
ATC code ?
PubChem
ChemSpider  YesY
Synonyms (3α,5α)-17-Phenyl-androst-16-en-3-ol
Chemical data
Formula C25H34O 
Mol. mass 350.535 g/mol
 N   

17-Phenylandrostenol (17-PA) is a steroid drug which binds to GABAA receptors. It acts as an antagonist against the sedative effects of neuroactive steroids, but has little effect when administered by itself, and does not block the effects of benzodiazepines or barbiturates.[1][2]

References

  1. ^ Mennerick S, He Y, Jiang X, Manion BD, Wang M, Shute A, Benz A, Evers AS, Covey DF, Zorumski CF (May 2004). "Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors". Molecular Pharmacology 65 (5): 1191–7.  
  2. ^ Kelley SP, Alan JK, O'Buckley TK, Mennerick S, Krishnan K, Covey DF, Leslie Morrow A (October 2007). "Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol". European Journal of Pharmacology 572 (2–3): 94–101.  



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