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2-Methyl-5-hydroxytryptamine

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Title: 2-Methyl-5-hydroxytryptamine  
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Subject: 5-Methoxytryptamine, 5-Carboxamidotryptamine, 5-(Nonyloxy)tryptamine, Bay R 1531, BW-723C86
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2-Methyl-5-hydroxytryptamine

2-Methyl-5-hydroxytryptamine
Systematic (IUPAC) name
3-(2-aminoethyl)-2-methyl-1H-indol-5-ol
Clinical data
Legal status
?
Identifiers
CAS number  N
ATC code ?
PubChem
IUPHAR ligand
ChemSpider  YesY
KEGG  YesY
ChEBI  YesY
ChEMBL  YesY
Chemical data
Formula C11H14N2O 
Mol. mass 190.242 g/mol
 N   

2-Methyl-5-hydroxytryptamine (2-Methylserotonin, 2-Methyl-5-HT) is a tryptamine derivative closely related to the neurotransmitter serotonin which acts as a moderately selective full agonist at the 5-HT3 receptor.[1][2][3]

See also

References

  1. ^ Elz S, Zimmermann H, Rehse K. (1993). "Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines.". Arch Pharm (Weinheim). 326 (11): 893–899.  
  2. ^ Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE. (1990). "5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.". Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9–16.  
  3. ^ Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. Archived from the original on 21 April 2008. Retrieved 2008-04-11. 


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