Alpha subunit of glycoprotein hormones

Glycoprotein hormones, alpha polypeptide
PDB rendering based on 1dz7.
Available structures
PDB Ortholog search: RCSB
Identifiers
CGA Gene
RNA expression pattern

Glycoprotein hormones alpha chain is a protein that in humans is encoded by the CGA gene.[1]

The hormones human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these four human glycoprotein hormones are nearly identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.[2]

The Alpha Chain has the following amino acid sequence:

NH2 - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH

The Beta Chain has the following amino acid sequence:

NH2 - Ser - Lys - Glu - Pro - Leu - Arg - Pro - Arg - Cys - Arg - Pro - Ile - Asn - Ala - Thr - Leu - Ala - Val - Glu - Lys - Glu - Gly - Cys - Pro - Val - Cys - Ile - Thr - Val - Asn - Thr - Thr - Ile - Cys - Ala - Gly - Tyr - Cys - Pro - Thr - Met - Thr - Arg - Val - Leu - Gln - Gly - Val - Leu - Pro - Ala - Leu - Pro - Gln - Val - Val - Cys - Asn - Tyr - Arg - Asp - Val - Arg - Phe - Glu - Ser - Ile - Arg - Leu - Pro - Gly - Cys - Pro - Arg - Gly - Val - Asn - Pro - Val - Val - Ser - Tyr - Ala - Val - Ala - Leu - Ser - Cys - Gln - Cys - Ala - Leu - Cys - Arg - Arg - Ser - Thr - Thr - Asp - Cys - Gly - Gly - Pro - Lys - Asp - His - Pro - Leu - Thr - Cys - Asp - Asp - Pro - Arg - Phe - Gln - Asp - Ser - Ser - Ser - Ser - Lys - Ala - Pro - Pro - Pro - Ser - Leu - Pro - Ser - Pro - Ser - Arg - Leu - Pro - Gly - Pro - Ser - Asp - Thr - Pro - Ile - Leu - Pro - Gln - COOH

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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