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Title: Bepotastine  
Author: World Heritage Encyclopedia
Language: English
Subject: List of drugs: Be, Talion
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
4-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
Clinical data
Pregnancy cat.
Legal status
  • Prescription only
Routes Oral, topical (eye drops)
Pharmacokinetic data
Bioavailability High (oral)
Minimal (topical)
Protein binding ~55%
Excretion Renal (75–90%)
CAS number  N
ATC code None
ChemSpider  Y
Chemical data
Formula C21H25ClN2O3 
Mol. mass 388.88 g/mol

Bepotastine (Talion) is a 2nd-generation antihistamine.[1] It was approved in Japan for use in the treatment of allergic rhinitis and urticaria/pruritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand name TALION. TALION was co-developed by Tanabe Seiyaku and Ube Industries, Ltd., who discovered bepotastine. In 2001, Tanabe Seiyaku granted Senju exclusive worldwide rights, with the exception of certain Asian countries, to develop, manufacture and market bepotastine for ophthalmic use. Senju, in turn, has granted the United States rights for the ophthalmic preparation to ISTA Pharmaceuticals, Inc., a specialty pharmaceutical company located in Irvine, CA.


  1. ^ H. Takahashi, A. Ishida-Yamamoto, H. Iizuka (September 2004). "Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance". Clinical and Experimental Dermatology 29: 526–532. doi:10.1111/j.1365-2230.2004.01618.x. 

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