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Cx-516

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Title: Cx-516  
Author: World Heritage Encyclopedia
Language: English
Subject: IDRA-21, PEPA (drug), LY-404,187, S-18986, Farampator
Collection: Amides, Ampa Receptor Agonists, Ampakines, Piperidines, Quinoxalines, Stimulants
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Cx-516

CX-516
Systematic (IUPAC) name
6-(piperidin-1-ylcarbonyl)quinoxaline
Pharmacokinetic data
Biological half-life 45 minutes
Identifiers
CAS Registry Number  YesY
PubChem CID:
IUPHAR/BPS
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEMBL  YesY
Chemical data
Formula C14H15N3O
Molecular mass 241.289 g/mol
 YesY   

CX-516 is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator and is being developed by a collaboration of Cortex and Shire and Servier. It was researched as a treatment for Alzheimer's disease under the brand name Ampalex, and was also being examined as a treatment for ADHD.

CX-516 was the first ampakine compound developed by Cortex and while it showed good in vitro activity and positive results in animal tests, the human trials proved disappointing due mainly to low potency and short half-life. However, CX-516 is still widely used in animal research into the ampakine drugs and is the standard reference compound that newer, more potent drugs of this class such as farampator and CX-717 are compared to.

See also

References

  • CX-516 therapy in Alzheimer's disease, schizophrenia and mild cognitive impairment



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