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Capillary

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Capillary

Capillary
Capillary vessel
Transmission electron microscope image of a capillary with a red blood cell within the pancreas. The capillary lining consists of long, thin endothelial cells, connected by tight junctions.
A simplified illustration of a capillary network (lacking precapillary sphincters, which are not present in all capillaries[1]).
Details
Latin vas capillare[2]
Identifiers
Code TH H3.09.02.0.02001
Anatomical terminology

Capillaries ( in US; in UK) are the smallest of a body's blood vessels and are parts of its microcirculation. Their endothelial linings are only one cell layer thick. These microvessels, measuring around 5 to 10 micrometre in diameter, connect arterioles and venules, and they help to enable the exchange of water, oxygen, carbon dioxide, and many other nutrients and waste chemical substances between blood and the tissues[3] surrounding them. During embryological development,[4] new capillaries are formed through vasculogenesis, the process of blood vessel formation that occurs through a de novo production of endothelial cells followed by their forming into vascular tubes.[5] The term angiogenesis denotes the formation of new capillaries from pre-existing blood vessels and already present endothelium which divides.[6]

Contents

  • Anatomy 1
    • Types 1.1
      • Continuous 1.1.1
      • Fenestrated 1.1.2
      • Sinusoidal 1.1.3
  • Physiology 2
    • Variables 2.1
  • Clinical significance 3
    • Therapeutics 3.1
    • Blood sampling 3.2
  • History 4
  • See also 5
  • References 6
  • External links 7

Anatomy

Simplified image showing flood-flow through the body, passing through capillary networks in its path.

Blood flows away from a body's heart via arteries, which branch and narrow into arterioles, and then branch further still into capillaries. After their tissues have been perfused, the capillaries then join and widen to become venules, which in turn widen and converge to become veins, which then return blood back to the body's heart through the different great veins.

Capillaries do not function on their own, but instead in a capillary bed, an interweaving network of capillaries supplying tissues. The more metabolically active a cell or environment is, the more capillaries are required to supply nutrients and carry away waste products. Capillary beds can consist of two types of vessels: true capillaries, which branch from arterioles and provide exchange between cells and the blood, and metarterioles, which are short vessels that directly connect the arterioles and venules at opposite ends of the bed.

  • Histology image: 00903loa - Histology Learning System at Boston University
  • {http://microcirc.org Microcirculatory Society, Inc}
  • {http://histology.leeds.ac.uk/circulatory/capillaries.php}

External links

  1. ^ a b c d Sakai et. al (2013). "Are the precapillary sphincters and metarterioles universal components of the microcirculation? An historical review". J Physiol Sci. 2013; 63: 319–331.  
  2. ^ "THH:3.09 The cardiovascular system". Retrieved June 3, 2014. 
  3. ^ Maton, Anthea; Jean Hopkins; Charles William McLaughlin; Susan Johnson; Maryanna Quon Warner; David LaHart; Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey: Prentice Hall.  
  4. ^ http://www.wormbook.org/chapters/www_embryovariationdevelop/embryovariationdevelop.html
  5. ^ John S. Penn (11 March 2008). Retinal and Choroidal Angiogenesis. Springer. pp. 119–.  
  6. ^ "Endoderm -- Developmental Biology -- NCBI Bookshelf". Retrieved 2010-04-07. 
  7. ^ Krstic, Radivoj V. (1991). Human Microscopic Anatomy: An Atlas for Students of Medicine and Biology. Springer. p. 52. 
  8. ^ Histology image:22401lba from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide.  
  9. ^ Pavelka, Margit; Jürgen Roth (2005). Functional Ultrastructure: An Atlas of Tissue Biology and Pathology. Springer. p. 232. 
  10. ^ Gittenberger-De Groot, Adriana C.; Winter, Elizabeth M.; Poelmann, Robert E (2010). "Epicardium derived cells (EPDCs) in development, cardiac disease and repair of ischemia". Journal of Cellular and Molecular Medicine 14 (5): 1056–60.  
  11. ^ a b Lambiase, P. D.; Edwards, RJ; Anthopoulos, P; Rahman, S; Meng, YG; Bucknall, CA; Redwood, SR; Pearson, JD; Marber, MS (2004). "Circulating Humoral Factors and Endothelial Progenitor Cells in Patients with Differing Coronary Collateral Support". Circulation 109 (24): 2986–92.  
  12. ^ Noon, J P; Walker, B R; Webb, D J; Shore, A C; Holton, D W; Edwards, H V; Watt, G C (1997). "Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure". Journal of Clinical Investigation 99 (8): 1873–9.  
  13. ^ Bird, Alan C. (2010). "Therapeutic targets in age-related macular disease". Journal of Clinical Investigation 120 (9): 3033–41.  
  14. ^ Cao, Yihai (2009). "Tumor angiogenesis and molecular targets for therapy". Frontiers in Bioscience 14 (14): 3962–73.  
  15. ^ Dr. Paul Ghalioungui (1982), "The West denies Ibn Al Nafis's contribution to the discovery of the circulation", Symposium on Ibn al-Nafis, Second International Conference on Islamic Medicine: Islamic Medical Organization, Kuwait (cf. The West denies Ibn Al Nafis's contribution to the discovery of the circulation, Encyclopedia of Islamic World)
  16. ^ John Cliff, Walter (1976). Blood Vessels. CUP Archives. p. 14. 

References

See also

Marcello Malpighi was the first to observe and correctly describe capillaries, discovering them in a frog's lung in 1661.[16]

Ibn al-Nafis theorized a "premonition of the capillary circulation in his assertion that the pulmonary vein receives what exits the pulmonary artery, explaining the existence of perceptible passages between the two."[15]

History

Capillary blood sampling is generally performed by creating a small cut using a blood lancet, followed by sampling by capillary action on the cut with a test strip or small pipe.

Capillary blood sampling can be used to test for, for example, blood glucose (such as in blood glucose monitoring), hemoglobin, pH and lactate (the two latter can be quantified in fetal scalp blood testing to check the acid base status of a fetus during childbirth).

Blood sampling

  • In patients with the retinal disorder, neovascular age-related macular degeneration, local anti-VEGF treatment to limit the bio-activity of vascular endothelial growth factor has been shown to protect vision by limiting progression.[13] In a wide range of cancers, treatment approaches have been studied, or are in development, aimed at decreasing tumour growth by reducing angiogenesis.[14]

Major diseases where altering capillary formation could be helpful include conditions where there is excessive or abnormal capillary formation such as cancer and disorders harming eyesight; and medical conditions in which there is reduced capillary formation either for familial or genetic reasons, or as an acquired problem.

Therapeutics

  • Formation of additional capillaries and larger blood vessels (angiogenesis) is a major mechanism by which a cancer may help to enhance its own growth. Disorders of retinal capillaries contribute to the pathogenesis of age-related macular degeneration.
  • Reduced capillary density (capillary rarefaction) occurs in association with cardiovascular [11]

Disorders of capillary formation as a [11]

Clinical significance

  1. Capillary hydrostatic pressure ( Pc )
  2. Interstitial hydrostatic pressure ( Pi )
  3. Capillary oncotic pressure ( πz )
  4. Interstitial oncotic pressure ( πi )
  5. Filtration coefficient ( Kf )
  6. Reflection coefficient ( σ )

According to Starling's equation, the movement of fluid depends on six variables:

Variables

By convention, outward force is defined as positive, and inward force is defined as negative. The solution to the equation is known as the net filtration or net fluid movement (Jv). If positive, fluid will tend to leave the capillary (filtration). If negative, fluid will tend to enter the capillary (absorption). This equation has a number of important physiologic implications, especially when pathologic processes grossly alter one or more of the variables.

  • ( [P_c - P_i] - \sigma[\pi_c - \pi_i] ) is the net driving force,
  • K_f is the proportionality constant, and
  • J_v is the net fluid movement between compartments.

where:

\ J_v = K_f ( [P_c - P_i] - \sigma[\pi_c - \pi_i] )

The Starling equation defines the forces across a semipermeable membrane and allows calculation of the net flux:

Depiction of the filtration and reabsorption present in capillaries.

Capillary permeability can be increased by the release of certain cytokines, anaphylatoxins, or other mediators (such as leukotrienes, prostaglandins, histamine, bradykinin, etc.) highly influenced by the immune system.

In the lungs special mechanisms have been adapted to meet the needs of increased necessity of blood flow during exercise. When the heart rate increases and more blood must flow through the lungs, capillaries are recruited and are also distended to make room for increased blood flow. This allows blood flow to increase while resistance decreases.

Capillary beds may control their blood flow via myogenic response, and in the kidney by tubuloglomerular feedback. When blood pressure increases, arterioles are stretched and subsequently constrict (a phenomenon known as the Bayliss effect) to counteract the increased tendency for high pressure to increase blood flow.

The capillary wall is a one-layer endothelium that allows gas and lipophilic molecules such as water and ions to pass through without the need for special transport mechanisms. This transport mechanism allows bidirectional diffusion depending on osmotic gradients and is further explained by the Starling equation.

Diagram of a capillary

Physiology

A capillary wall is only 1 cell thick and is simple squamous epithelium.

  • Sinusoidal capillaries are a special type of fenestrated capillaries that have larger openings (30-40 μm in diameter) in the endothelium. These types of blood vessels allow red and white blood cells (7.5μm - 25μm diameter) and various serum proteins to pass aided by a discontinuous basal lamina. These capillaries lack pinocytotic vesicles, and therefore utilize gaps present in cell junctions to permit transfer between endothelial cells, and hence across the membrane. Sinusoid blood vessels are primarily located in the bone marrow, lymph nodes, and adrenal gland. Some sinusoids are special, in that they do not have the tight junctions between cells. They are called discontinuous sinusoidal capillaries, and are present in the liver and spleen where greater movement of cells and materials is necessary.

Sinusoidal

  • Fenestrated capillaries (derived from "fenestra," Latin for "window") have pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse.[8][9] In the renal glomerulus there are cells with no diaphragms called podocyte foot processes or "pedicels," which have slit pores with an analogous function to the diaphragm of the capillaries. Both of these types of blood vessels have continuous basal lamina and are primarily located in the endocrine glands, intestines, pancreas, and glomeruli of kidney.

Fenestrated

  1. Those with numerous transport vesicles that are primarily found in skeletal muscles, finger, gonads, and skin.
  2. Those with few vesicles that are primarily found in the central nervous system. These capillaries are a constituent of the blood brain barrier.
  • Continuous capillaries are continuous in the sense that the endothelial cells provide an uninterrupted lining, and they only allow smaller molecules, such as water and ions to diffuse through tight junctions, leaving gaps of membranes called intercellular clefts. Tight junctions can be further divided into two subtypes:

Continuous

Depiction of the major types of capillaries, showing fenestrations as well as intercellular gaps.

There are three main types of capillaries:

Types

[1]

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