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Clovoxamine

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Clovoxamine

Clovoxamine
Systematic (IUPAC) name
1-(4-chlorophenyl)-5-methoxypentan-1-one O-2-aminoethyl oxime
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Identifiers
CAS number  Y
ATC code None
PubChem
ChemSpider  N
UNII  Y
ChEMBL  N
Chemical data
Formula C14H21ClN2O2 
Mol. mass 284.78 g/mol
 N   

Clovoxamine is a drug that was discovered in the 1970s and subsequently investigated as an antidepressant and anxiolytic agent.[1][2][3] It acts as a serotonin-norepinephrine reuptake inhibitor (SNRI), with little affinity for the muscarinic acetylcholine, histamine, adrenergic, and serotonin receptors.[4][5] It is structurally related to fluvoxamine.

References

  1. ^ Freeman; Wakelin, J. S.; Calanca, A.; Hole, G. (1982). "Initial clinical evaluation of a new nontricyclic antidepressant: clovoxamine". Advances in biochemical psychopharmacology 32: 69–75. PMID 7046368. 
  2. ^ Jesinger; Gostick, N. (1989). "Anxiety neurosis in general practice. A double-blind comparative study of diazepam and clovoxamine, a novel inhibitor of noradrenaline and serotonin reuptake". International clinical psychopharmacology 4 (4): 301–311. PMID 2691573. doi:10.1097/00004850-198910000-00005. 
  3. ^ Hurst; Jones, D. R.; Wright, J. H.; Jarboe, C. H. (1983). "Clovoxamine kinetics in an early clinical trial". Clinical pharmacology and therapeutics 34 (2): 266–271. PMID 6872422. doi:10.1038/clpt.1983.164. 
  4. ^ Saletu; Grünberger, J.; Rajna, P.; Karobath, M. (1980). "Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man". Journal of neural transmission 49 (1–2): 63–86. PMID 6777458. doi:10.1007/BF01249190. 
  5. ^ Bradford; Tulp, M. T.; Schipper, J. (1987). "Biochemical effects in rats after acute and long-term treatment with clovoxamine". Archives internationales de pharmacodynamie et de therapie 287 (2): 188–202. PMID 2820327. 



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