World Library  
Flag as Inappropriate
Email this Article

Demecolcine

Article Id: WHEBN0020362448
Reproduction Date:

Title: Demecolcine  
Author: World Heritage Encyclopedia
Language: English
Subject: Cytoskeletal drugs, Chemotherapy, Cell-cycle nonspecific antineoplastic agents, Hazardous drugs, Thiopurine
Collection: Alkaloids, Heptalenes, Ketones, Microtubule Inhibitors, Phenol Ethers
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Demecolcine

Demecolcine
Systematic (IUPAC) name
(S)-1,2,3,10-Tetramethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code L01
PubChem
ChemSpider  YesY
UNII  YesY
ChEMBL  YesY
Chemical data
Formula C21H25NO5 
Mol. mass 371.43 g/mol
 YesY   

Demecolcine, also known as colcemid, is a drug used in chemotherapy.It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic. It depolymerises microtubules and limits microtubule formation (inactivates spindle fibre formation), thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed.

During cell division Demecolcine inhibits mitosis at metaphase by inhibiting spindle formation. Medically Demecolcine has been used to improve the results of cancer radiotherapy by synchronising tumour cells at metaphase, the radiosensitive stage of the cell cycle.[1]

In animal cloning procedures Demecolcine makes an ovum eject its nucleus, creating space for insertion of a new nucleus.[2]

Mechanism of Action

Demecolcine is a microtubule-depolymerizing drug like microtubule detachment.[4] Lower concentration affects microtubule dynamics and cell migration.[4]

References

  1. ^ Brit med J., 1965, 1, 495 – 496
  2. ^ Reprod Nutr Dev. 2006 Mar-Apr;46(2):219-26
  3. ^ Jordan, Mary Ann; Wilson, Leslie (2004). "Microtubules as a target for anticancer drugs". Nature reviews. Cancer 4 (4): 253–65.  
  4. ^ a b Yang, Hailing; Ganguly, Anutosh; Cabral, Fernando (2010). "Inhibition of cell migration and cell division correlate with distinct effects of microtubule inhibiting drugs". The Journal of Biological Chemistry 285 (42): 32242–50.  


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.