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Diacylglycerol lipase

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Title: Diacylglycerol lipase  
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Subject: R.EcoRII, Phospholipase A2, EC 3.1, 5-lipoxygenase-activating protein, Esterases
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Diacylglycerol lipase

diacylglycerol lipase, alpha
Symbol DAGLA
Alt. symbols C11orf11
Entrez 747
HUGO 1165
RefSeq NM_006133
UniProt Q9Y4D2
Other data
EC number 3.1.1.-
Locus Chr. 11 q12.3
diacylglycerol lipase, beta
Symbol DAGLB
Entrez 221955
HUGO 28923
RefSeq NM_139179
UniProt Q8NCG7
Other data
EC number 3.1.1.-
Locus Chr. 7 p22.1

Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol.

Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.


The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.


  1. ^ Bisogno T, Howell F, Williams G; et al. (November 2003). "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain". J. Cell Biol. 163 (3): 463–8.  

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