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Discoidin domain-containing receptor 2

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Title: Discoidin domain-containing receptor 2  
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Subject: DDR1, Fibroblast growth factor receptor 4, TEK tyrosine kinase, Kinase insert domain receptor, PDGFRB
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Discoidin domain-containing receptor 2

Discoidin domain receptor tyrosine kinase 2

Rendering based on PDB .
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; MIG20a; NTRKR3; TKT; TYRO10
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Discoidin domain-containing receptor 2, also known as CD167b (cluster of differentiation 167b), is a protein that in humans is encoded by the DDR2 gene.[1] Discoidin domain-containing receptor 2 is a receptor tyrosine kinase (RTK).

Function

RTKs play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. In the case of DDR2, the ligand is collagen which binds to its extracellular discoidin domain. [2] This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. DDR2 has been associated with a number of diseases including fibrosis and cancer. [3]

Structure

RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain.[1]

Gene

Alternative splicing in the 5' UTR of the DDR2 gene results in multiple transcript variants encoding the same protein.[1]

Interactions

DDR2 (gene) has been shown to interact with SHC1[4] and phosphorylate Shp2.[5] DDR2 also interacts with Integrin α1β1 and α2β1 by promoting their adhesion to collagen. [6]

References

  1. ^ a b c "Entrez Gene: DDR2 discoidin domain receptor family, member 2". 
  2. ^ Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R (March 2013). "Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.". J. Biol Chem. 288 (11): 7430–9.  
  3. ^ Leitinger B (May 2011). "Transmembrane collagen receptors.". Annu Rev Cell Dev Biol. 27: 265–90.  
  4. ^ Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC (May 2002). "Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen". J. Biol. Chem. 277 (21): 19206–12.  
  5. ^ Iwai LK, Payne LS, Luczynski MT, Chang F, Xu H, Clinton RW, Paul A, Esposito EA, Gridley S, Leitinger B, Naegle KM, Huang PH (July 2013). "Phosphoproteomics of Collagen Receptor Networks Reveals SHP-2 Phosphorylation Downstream of Wildtype DDR2 and its Lung Cancer Mutants". Biochem. J. 454 (3): 501–13.  
  6. ^ Xu H, Bihan D, Chang F, Huang PH, Farndale RW, Leitinger B (Dec 2012). "Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation". PLoS ONE 7 (12): e52209.  

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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