Gpr113

G protein-coupled receptor 113
Identifiers
GPR113 Gene
Orthologs
SpeciesHumanMouse

GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein.[1][2]

Gene

The Homo sapiens GPR113 gene is located on chromosome 2 (2p23.3). This gene spans the length of a 38.65kb region from base 26531041 to 26569685 on the negative strand.EPT1 gene. The GPR113 gene is also known by the aliases PGR23 and HGPCR37.[4]

Homology & Evolution

The GPR113 has 5 human paralogs Homologous domains that are well conserved throughout orthologs center in the

Protein

The protein product of GPR113 gene is a G-protein coupled receptor. The protein has three transcript variants in humans.Domain of unknown function that is not highlighted.

Function

GPR113 is a G protein-coupled receptor that is involved in a neuropeptide signaling pathway.[8]

Expression & Disease

GPR113 has been found to be expressed differentially under diseased conditions. Under the condition of Type 2 diabetes, the percentile rank relative to other transcripts decreases relative to normal cell function.[9] The deletion of TP63, which mediates a wide variety of important body processes, also produces decreased GPR113 expression.[10] In mice brains, the cerebellum and the olfactory bulb both show transciption of the GPR113 gene.[11] Additionally, a study from the National Institute of Deafness and Other Communication Disorders has identified GPR113 expression to be highly restricted to a subset of taste receptor cells.[12] This paper's conclusions, coupled with olfactory bulb expression levels, could provide an avenue for future research, potentially illuminating more about GPR113's function.

Interacting Proteins

GPR113 has been shown to associate with the orphan G protein-coupled receptor GPR123.[13]

Transcription Factors

Top 10 Transcription factors of highest likelihood[14]
Binding site for S8 type homeodomains
Binding site for S8 type homeodomains
DLX-1, -2, and -5 binding sites
TCF/LEF-1 (secondary DNA binding preference)
Homeobox containing germ cell-specific transcription factor NOBOX
Spalt-like transcription factor 1
Transcriptional repressor CDP
Alternative splicing variant of FOXP1, activated in ESCs
Binding site for S8 type homeodomains
Homeobox containing germ cell-specific transcription factor NOBOX

Clinical Significance

The clinical significance of this protein has not been established. However, the expression profiles provide exciting directions for future research of the GPR113 gene, especially in fields studying taste and smell.


References

Further reading

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