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Hla-dpb1

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Title: Hla-dpb1  
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Subject: Major histocompatibility complex, Human leukocyte antigen, Chromosome 6 (human), HLA-DR, MHC class II, HLA-DP
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Hla-dpb1

Major histocompatibility complex, class II, DP beta 1
Available structures
PDB Ortholog search: RCSB
Identifiers
HLA-DPB1 Gene
RNA expression pattern

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.[1]

See also

References

Further reading

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