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HMG-CoA

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Title: HMG-CoA  
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Subject: HMG-CoA reductase, Metabolic intermediate, Phosphomevalonic acid, Mevalonate pathway, 3-hydroxy-3-methylglutaryl-CoA lyase
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HMG-CoA

HMG-CoA
Names
IUPAC name
(9R,21S)-1-[(2R,3S,4R,5R)-5-

(6-amino-9H-purin-9-yl)-4-hydroxy- 3-(phosphonooxy)tetrahydrofuran-2-yl]- 3,5,9,21-tetrahydroxy-8,8,21-trimethyl- 10,14,19-trioxo-2,4,6-trioxa-18-thia- 11,15-diaza-3,5-diphosphatricosan-23-

oic acid 3,5-dioxide
Identifiers
 YesY
ChEBI  YesY
ChemSpider  YesY
Jmol-3D images Image
MeSH
PubChem
Properties
C27H44N7O20P3S
Molar mass 911.661 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 YesY  (: YesY/N?)

HMG-CoA (or 3-hydroxy-3-methylglutaryl-coenzyme A) is an intermediate in the mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase.

It is also an intermediate in the metabolism of leucine. Its immediate precursor is 3-methylglutaconyl CoA.

Mevalonate pathway

HMG-CoA reductase converts it into mevalonic acid.

Mevalonate pathway

Ketogenesis pathway

HMG-CoA lyase breaks it into acetyl CoA and acetoacetate.


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