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Hydrogel

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Hydrogel

For other uses, see Gel (disambiguation).

A gel (from the lat. gelu—freezing, cold, ice or gelatus—frozen, immobile) is a solid, jelly-like material that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state.[1] By weight, gels are mostly liquid, yet they behave like solids due to a three-dimensional cross-linked network within the liquid. It is the crosslinking within the fluid that give a gel its structure (hardness) and contribute to the adhesive stick (tack).[2] In this way gels are a dispersion of molecules of a liquid within a solid in which the solid is the continuous phase and the liquid is the discontinuous phase.

IUPAC definition

Gel:Nonfluid colloidal network or polymer network that is expanded throughout its whole
volume by a fluid.[3]

Note 1: A gel has a finite, usually rather small, yield stress.

Note 2: A gel can contain:

(i) a covalent polymer network, e.g., a network formed by crosslinking polymer chains
or by nonlinear polymerization;
(ii) a polymer network formed through the physical aggregation of polymer chains,
caused by hydrogen bonds, crystallization, helix formation, complexation, etc., that
results in regions of local order acting as the network junction points. The resulting
swollen network may be termed a “thermoreversible gel” if the regions of local order
are thermally reversible;
(iii) a polymer network formed through glassy junction points, e.g., one based on
block copolymers. If the junction points are thermally reversible glassy domains, the
resulting swollen network may also be termed a thermoreversible gel;
(iv) lamellar structures including mesophases {Ref.[4] defines lamellar crystal and
mesophase}, e.g., soap gels, phospholipids, and clays;
(v) particulate disordered structures, e.g., a flocculent precipitate usually consisting
of particles with large geometrical anisotropy, such as in V2O5 gels and globular
or fibrillar protein gels.

Note 3: Corrected from ref.,[5] where the definition is via the property identified in Note 1
(above) rather than of the structural characteristics that describe a gel.[6]

Hydrogel: Gel in which the swelling agent is water.

Note 1: The network component of a hydrogel is usually a polymer network.

Note 2: A hydrogel in which the network component is a colloidal network may be referred
to as an aquagel.

Note 3: Definition quoted from refs.[6][7]

[8]

Composition

Gels consist of a solid three-dimensional network that spans the volume of a liquid medium and ensnares it through surface tension effects. This internal network structure may result from physical bonds (physical gels) or chemical bonds (chemical gels), as well as crystallites or other junctions that remain intact within the extending fluid. Virtually any fluid can be used as an extender including water (hydrogels), oil, and air (aerogel). Both by weight and volume, gels are mostly fluid in composition and thus exhibit densities similar to those of their constituent liquids. Edible jelly is a common example of a hydrogel and has approximately the density of water.

Cationic polymers

Cationic polymers are positively charged polymers. Their positive charges prevent the formation of coiled polymers. This allows them to contribute more to viscosity in their stretched state, because the stretched-out polymer takes up more space. Gel is a colloid solution of dispersion phase as liquid and dispersion medium as solid.

Types

Hydrogels

Hydrogel is a network of polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium. Hydrogels are highly absorbent (they can contain over 99.9% water) natural or synthetic polymers. Hydrogels also possess a degree of flexibility very similar to natural tissue, due to their significant water content. Common uses for hydrogels include:

  • currently used as scaffolds in tissue engineering. When used as scaffolds, hydrogels may contain human cells to repair tissue.
  • hydrogel-coated wells have been used for cell culture[9]
  • environmentally sensitive hydrogels which are also known as 'Smart Gels' or 'Intelligent Gels'. These hydrogels have the ability to sense changes of pH, temperature, or the concentration of metabolite and release their load as result of such a change.
  • as sustained-release drug delivery systems.
  • provide absorption, desloughing and debriding of necrotic and fibrotic tissue.
  • hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors, as well as in DDS.
  • used in disposable diapers where they absorb urine, or in sanitary napkins
  • contact lenses (silicone hydrogels, polyacrylamides)
  • EEG and ECG medical electrodes using hydrogels composed of cross-linked polymers (polyethylene oxide, polyAMPS and polyvinylpyrrolidone)
  • water gel explosives
  • rectal drug delivery and diagnosis
  • encapsulation of quantum dots

Other, less common uses include

Common ingredients are e.g. polyvinyl alcohol, sodium polyacrylate, acrylate polymers and copolymers with an abundance of hydrophilic groups.

Natural hydrogel materials are being investigated for tissue engineering; these materials include agarose, methylcellulose, hyaluronan, and other naturally derived polymers.

Organogels

An organogel is a non-crystalline, non-glassy thermoreversible (thermoplastic) solid material composed of a liquid organic phase entrapped in a three-dimensionally cross-linked network. The liquid can be, for example, an organic solvent, mineral oil, or vegetable oil. The solubility and particle dimensions of the structurant are important characteristics for the elastic properties and firmness of the organogel. Often, these systems are based on self-assembly of the structurant molecules.[10][11]

Organogels have potential for use in a number of applications, such as in pharmaceuticals,[12] cosmetics, art conservation,[13] and food.[14] An example of formation of an undesired thermoreversible network is the occurrence of wax crystallization in petroleum.[15]

Xerogels

A xerogel /ˈzɪərɵɛl/ is a solid formed from a gel by drying with unhindered shrinkage. Xerogels usually retain high porosity (15–50%) and enormous surface area (150–900 m2/g), along with very small pore size (1–10 nm). When solvent removal occurs under hypercritical (supercritical) conditions, the network does not shrink and a highly porous, low-density material known as an aerogel is produced. Heat treatment of a xerogel at elevated temperature produces viscous sintering (shrinkage of the xerogel due to a small amount of viscous flow) and effectively transforms the porous gel into a dense glass.

Properties

Many gels display thixotropy – they become fluid when agitated, but resolidify when resting. In general, gels are apparently solid, jelly-like materials. By replacing the liquid with gas it is possible to prepare aerogels, materials with exceptional properties including very low density, high specific surface areas, and excellent thermal insulation properties.

Animal produced

Some species secrete gels that are effective in parasite control. For example, the long-finned pilot whale secretes an enzymatic gel that rests on the outer surface of this animal and helps prevent other organisms from establishing colonies on the surface of these whales' bodies.[16]

Hydrogels existing naturally in the body include mucus, the vitreous humor of the eye, cartilage, tendons and blood clots. Their viscoelastic nature results in the soft tissue component of the body, disparate from the mineral-based hard tissue of the skeletal system. Researchers are actively developing synthetically derived tissue replacement technologies derived from hydrogels, for both temporary implants (degradable) and permanent implants (non-degradable). A review article on the subject discusses the use of hydrogels for nucleus pulposus replacement, cartilage replacement, and synthetic tissue models.[17]

Applications

Many substances can form gels when a suitable thickener or gelling agent is added to their formula. This approach is common in manufacture of wide range of products, from foods to paints and adhesives.

In fiber optics communications, a soft gel resembling "hair gel" in viscosity is used to fill the plastic tubes containing the fibers. The main purpose of the gel is to prevent water intrusion if the buffer tube is breached, but the gel also buffers the fibers against mechanical damage when the tube is bent around corners during installation, or flexed. Additionally, the gel acts as a processing aid when the cable is being constructed, keeping the fibers central whilst the tube material is extruded around it.

See also

References

External links

  • Xerogel (definition)

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