Interleukin-27

Interleukin 27
Identifiers
Symbol IL27
Alt. symbols IL30, p28
Entrez HUGO OMIM RefSeq UniProt Locus p11
Epstein-Barr virus induced 3
Identifiers
Symbol EBI3
Alt. symbols IL-27B
Entrez HUGO OMIM RefSeq UniProt Locus p13

Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits; Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30).[1] IL-27 is produced by antigen-presenting cells.[2]

IL-27 plays an important function in regulating the activity of B- and T-lymphocytes.[3] The effects of IL-27 are eliciting by its interaction with a specific cell-surface receptor complex composed of two proteins known as IL27R and gp130.[4]

References

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