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Ly-487,379

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Ly-487,379

LY-487,379
Systematic (IUPAC) name
N-(4-(2-methoxyphenoxy)phenyl)- N-(2,2,2-trifluoroethylsulfonyl)pyrid- 3-ylmethylamine
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
PubChem
IUPHAR ligand
ChemSpider  N
ChEMBL  N
Chemical data
Formula C21H19F3N2O4S 
Mol. mass 452.446 g/mol
 N   

LY-487,379 is a drug used in scientific research that acts as a selective positive allosteric modulator for the metabotropic glutamate receptor group II subtype mGluR2.[1] It is used to study the structure and function of this receptor subtype,[2][3] and LY-487,379 along with various other mGluR2/3 agonists and positive modulators are being investigated as possible antipsychotic and anxiolytic drugs.[4][5][6][7][8]

See also

References

  1. ^ Johnson, M. P.; Baez, M.; Jagdmann, G. E.; Britton, T. C.; Large, T. H.; Callagaro, D. O.; Tizzano, J. P.; Monn, J. A.; Schoepp, D. D. (2003). "Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor:  Synthesis and Subtype Selectivity ofN-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine".  
  2. ^ Schaffhauser, H.; Rowe, B. A.; Morales, S.; Chavez-noriega, L. E.; Yin, R.; Jachec, C.; Rao, S. P.; Bain, G. et al. (2003). "Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2". Molecular Pharmacology 64 (4): 798–810.  
  3. ^ Poisik, O.; Raju, D. V.; Verreault, M.; Rodriguez, A.; Abeniyi, O. A.; Conn, P. J.; Smith, Y. (2005). "Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus". Neuropharmacology 49: 57–50.  
  4. ^ Galici, R.; Echemendia, N. G.; Rodriguez, A. L.; Conn, P. J. (2005). "A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity". Journal of Pharmacology and Experimental Therapeutics 315 (3): 1181–7.  
  5. ^ Marino; Conn, P. (2006). "Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors". Current Opinion in Pharmacology 6 (1): 98–102.  
  6. ^ Harich; Gross, G.; Bespalov, A. (2007). "Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment". Psychopharmacology 192 (4): 511–519.  
  7. ^ Conn, P. J.; Jones, C. K. (2009). "Promise of mGluR2/3 activators in psychiatry". Neuropsychopharmacology 34 (1): 248–249.  
  8. ^ Hermes, M. L. H. J.; Renaud, L. P. (2010). "Postsynaptic and Presynaptic Group II Metabotropic Glutamate Receptor Activation Reduces Neuronal Excitability in Rat Midline Paraventricular Thalamic Nucleus". Journal of Pharmacology and Experimental Therapeutics 336 (3): 840–849.  


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