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Mertk

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Mertk

C-mer proto-oncogene tyrosine kinase
PDB rendering based on 2dbj.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.10.1
Orthologs
SpeciesHumanMouse

Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.[1][2][3]

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).[3]

References

Further reading

External links

  • GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview


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