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Melanin-concentrating hormone receptor 1

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Title: Melanin-concentrating hormone receptor 1  
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Melanin-concentrating hormone receptor 1

Melanin-concentrating hormone receptor 1
Identifiers
MCHR1 Gene
RNA expression pattern

Melanin-concentrating hormone receptor 1, also known as MCH1, is one of the human melanin-concentrating hormone receptors.[1]

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.[1]

Function

MCH1 is thought to have a number of functions including in the regulation of appetite,[2][3] and in stress, anxiety and depression.[4][5][6][7][8][9]

Selective Ligands

Agonists

Antagonists

See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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