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Sb-612,111

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Title: Sb-612,111  
Author: World Heritage Encyclopedia
Language: English
Subject: J-113,397, Nociceptin receptor, List of opioids, JTC-801, Kobret
Collection: Alcohols, Annulenes, Chloroarenes, Nociceptin Receptor Antagonists, Opioids, Organochlorides, Piperidines
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Sb-612,111

SB-612,111
Systematic (IUPAC) name
(5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol
Clinical data
Legal status
?
Identifiers
CAS number  N
ATC code ?
PubChem
IUPHAR ligand
ChemSpider  N
ChEMBL  N
Synonyms SB-612,111
Chemical data
Formula C24H29Cl2NO 
Mol. mass 418.398 g/mol
 N   

SB-612,111 is an opioid receptor ligand which is a potent and selective antagonist for the nociceptin receptor (ORL-1), several times more potent than the older drug J-113,397.[1] It does not have analgesic effects in its own right, but prevents the development of hyperalgesia,[2] and also shows antidepressant effects in animal studies.[3]

See also

References

  1. ^ Spagnolo, B; Carrà, G; Fantin, M; Fischetti, C; Hebbes, C; McDonald, J; Barnes, TA; Rizzi, A et al. (2007). "Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-ylmethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol: in vitro studies". The Journal of Pharmacology and Experimental Therapeutics 321 (3): 961–7.  
  2. ^ Zaratin, PF; Petrone, G; Sbacchi, M; Garnier, M; Fossati, C; Petrillo, P; Ronzoni, S; Giardina, GA; Scheideler, MA (2004). "Modification of nociception and morphine tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-ylmethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)". The Journal of Pharmacology and Experimental Therapeutics 308 (2): 454–61.  
  3. ^ Rizzi, A; Gavioli, EC; Marzola, G; Spagnolo, B; Zucchini, S; Ciccocioppo, R; Trapella, C; Regoli, D; Calò, G (2007). "Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-ylmethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol: in vivo studies". The Journal of Pharmacology and Experimental Therapeutics 321 (3): 968–74.  



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