World Library  
Flag as Inappropriate
Email this Article

(Z)-4-Amino-2-butenoic acid

Article Id: WHEBN0020220782
Reproduction Date:

Title: (Z)-4-Amino-2-butenoic acid  
Author: World Heritage Encyclopedia
Language: English
Subject: N4-Chloroacetylcytosine arabinoside, GABA transaminase inhibitor, (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid, Gabaculine, GABA receptor antagonist
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

(Z)-4-Amino-2-butenoic acid

(Z)-4-Amino-2-butenoic acid[1]
CACA molecule
Identifiers
Abbreviations CACA
CAS number
PubChem
ChemSpider  YesY
ChEMBL  YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C4H7NO2
Molar mass 101.10 g mol−1
Solubility in water 124 mg/mL
Hazards
S-phrases S22 S24/25
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

(Z)-4-Amino-2-butenoic acid (CACA, cis-4-aminocrotonic acid) is a GABA receptor partial agonist selective for the GABAA (previously known as GABAC) subtype.[2][3][4]

References

  1. ^ -4-Aminocrotonic acidcis at Sigma-Aldrich
  2. ^ Qian, H; Dowling, JE (1996). "Selective agonists for GABAC receptors". Trends in neurosciences 19 (5): 190.  
  3. ^ Duke, RK; Chebib, M; Balcar, VJ; Allan, RD; Mewett, KN; Johnston, GA (2000). "(+)- and (-)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors". Journal of Neurochemistry 75 (6): 2602–10.  
  4. ^ Reis, GM; Duarte, ID (2007). "Involvement of chloride channel coupled GABA(C) receptors in the peripheral antinociceptive effect induced by GABA(C) receptor agonist cis-4-aminocrotonic acid". Life Sciences 80 (14): 1268–73.  


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.