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8-Phenyltheophylline

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Title: 8-Phenyltheophylline  
Author: World Heritage Encyclopedia
Language: English
Subject: 8-Chlorotheophylline, 8-Cyclopentyl-1,3-dimethylxanthine, SCH-58261, Xanthine, Dimethazan
Collection: Adenosine Receptor Antagonists, Xanthines
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8-Phenyltheophylline

8-Phenyltheophylline
Skeletal formula of 8-phenyltheophylline
Ball-and-stick model of the 8-phenyltheophylline molecule
Systematic (IUPAC) name
8-phenyl-1,3-dimethyl-7H-purine-2,6-dione
Identifiers
CAS Registry Number  N
PubChem CID:
ChemSpider  YesY
ChEMBL  YesY
Chemical data
Formula C13H12N4O2
Molecular mass 256.259 g/mol
 N   

8-Phenyltheophylline (8-Phenyl-1,3-dimethylxanthine, 8-PT) is a drug derived from the xanthine family which acts as a potent and selective antagonist for the adenosine receptors A1 and A2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor.[1][2][3] It has stimulant effects in animals with similar potency to caffeine.[4] Coincidentally 8-phenyltheophylline has also been found to be a potent and selective inhibitor of the liver enzyme CYP1A2 which makes it likely to cause interactions with other drugs which are normally metabolised by CYP1A2.[5]

See also

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