Alg2

ALG2, alpha-1,3/1,6-mannosyltransferase
Identifiers
2.4.1.132, 2.4.1.257
Orthologs
SpeciesHumanMouse

Alpha-1,3-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene.[1] Mutations in the human gene are associated with congenital defects in glycosylation [1][2]

This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii).[2]

Interactions

ALG2 has been shown to interact with ANXA7[3] and ANXA11.[3]

References

Further reading

  • NB ALG-2 is NOT the protein product of the ALG2 gene.
  • NB ALG-2 is NOT the protein product of the ALG2 gene.
  • NB ALG-2 is NOT the protein product of the ALG2 gene.
  • NB ALG-2 is NOT the protein product of the ALG2 gene.
  • NB ALG-2 is NOT the protein product of the ALG2 gene.

External links

  • GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview



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