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As-8112

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Title: As-8112  
Author: World Heritage Encyclopedia
Language: English
Subject: 5-HT3 receptor, List of dopaminergic drugs, Spiroxatrine, OSU-6162, Flibanserin
Collection: 5-Ht3 Antagonists, Antiemetics, Bromoarenes, Diazepanes, Dopamine Antagonists, Organobromides, Phenol Ethers, Salicylamides
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As-8112

AS-8112
Identifiers
PubChem
ChemSpider  YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C17H27BrN4O2
Molar mass 399.325 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3.[1] It has potent antiemetic effects in animal studies and has been investigated for potential medical use.[2][3]


References

  1. ^ Yoshikawa T, Yoshida N, Oka M (May 2001). "The broad-spectrum anti-emetic activity of AS-8112, a novel dopamine D2, D3 and 5-HT3 receptors antagonist".  
  2. ^ Yoshikawa T, Yoshida N, Oka M (November 2001). "Central antiemetic effects of AS-8112, a dopamine D2, D3, and 5-HT(3) receptor antagonist, in ferrets". European Journal of Pharmacology 431 (3): 361–4.  
  3. ^ Hirokawa Y, Fujiwara I, Suzuki K, Harada H, Yoshikawa T, Yoshida N, Kato S (February 2003). "Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity". Journal of Medicinal Chemistry 46 (5): 702–15.  


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