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Amidorphin

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Title: Amidorphin  
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Subject: List of opioids, Neoendorphin, DADLE, Leumorphin, Valorphin
Collection: Analgesics, Neurotransmitters, Opioid Peptides
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Amidorphin

Amidorphin
Identifiers
CAS number  YesY
PubChem
ChemSpider  YesY
Jmol-3D images Image 1
Properties
Molecular formula C131H200N30O43S2
Molar mass 2947.29 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

Amidorphin is an endogenous, C-terminally amidated, opioid peptide generated as a cleavage product of proenkephalin A that is widely distributed in the mammalian brain, with particularly high concentrations found in the adrenal medulla, posterior pituitary, and striatum.[1][2] In some brain areas, amidorphin is extensively further reduced into smaller fragments, such as the non-opioid peptide amidorphin-(8-26) which lacks the N-terminal [Met]enkephalin sequence of amidorphin; accordingly, [Met]enkephalin may also be a cleavage product of amidorphin.[3]

See also

References

  1. ^ Seizinger BR, Liebisch DC, Gramsch C et al. (1985). "Isolation and structure of a novel C-terminally amidated opioid peptide, amidorphin, from bovine adrenal medulla". Nature 313 (5997): 57–9.  
  2. ^ Liebisch DC, Seizinger BR, Michael G, Herz A (November 1985). "Novel opioid peptide amidorphin: characterization and distribution of amidorphin-like immunoreactivity in bovine, ovine, and porcine brain, pituitary, and adrenal medulla". Journal of Neurochemistry 45 (5): 1495–503.  
  3. ^ Liebisch DC, Weber E, Kosicka B, Gramsch C, Herz A, Seizinger BR (March 1986). "Isolation and structure of a C-terminally amidated nonopioid peptide, amidorphin-(8-26), from bovine striatum: a major product of proenkephalin in brain but not in adrenal medulla". Proceedings of the National Academy of Sciences of the United States of America 83 (6): 1936–40.  


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