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Title: Antiestrogen  
Author: World Heritage Encyclopedia
Language: English
Subject: Medroxyprogesterone acetate, Delmadinone acetate, Cyproterone acetate, Estrone sulfate, Nomegestrol acetate
Collection: Antiestrogens, Hormonal Agents, Hormonal Antineoplastic Drugs, Sex Hormones
Publisher: World Heritage Encyclopedia


An antiestrogen is a substance that blocks the production or utilization of maintenance of female sex characteristics.)

Antiestrogens like tamoxifen can promote an invasive phenotype in estrogen receptor (ER)-positive breast cancer cells with deficient intercellular adhesion.

Although aromatase inhibitors could be considered antiestrogens by some definitions, they are often considered to be a distinct class.[3] Aromatase inhibitors reduce the production of estrogen, while the term "antiestrogen" is usually reserved for agents reducing the response to estrogen.

See also


  1. ^ "Definition of antiestrogen - NCI Dictionary of Cancer Terms, Definition of antiestrogen - NCI Dictionary of Cancer Terms". ,
  2. ^ "antiestrogen" at Dorland's Medical Dictionary
  3. ^ Riggins RB, Bouton AH, Liu MC, Clarke R (2005). "Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer". Vitam. Horm. 71: 201–37.  

External links

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 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

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