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Arginine vasopressin receptor 2

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Title: Arginine vasopressin receptor 2  
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Arginine vasopressin receptor 2

Arginine vasopressin receptor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; ADHR; DI1; DIR; DIR3; NDI; V2R
External IDs IUPHAR: ChEMBL: GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Arginine vasopressin receptor 2 (officially abbreviated AVPR2) is a protein that acts as receptor for arginine vasopressin.[1] AVPR2 belongs to the subfamily of G-protein-coupled receptors. Its activity is mediated by the Gs type of G proteins, which stimulate adenylate cyclase.

AVPR2 is expressed in the kidney tubule, predominantly in the membrane of cells of the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. AVPR2 is also expressed outside the kidney, and, when stimulated, a variety of clotting factors are released into the bloodstream.

In the kidney, AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the Nephrogenic Diabetes Insipidus (NDI) results.

Contents

  • Antagonists 1
  • Interactions 2
  • References 3
  • Further reading 4
  • External links 5

Antagonists

Vasopressin receptor antagonists that are selective for the V2 receptor include:

Their main uses are in hyponatremia, such as that caused by syndrome of inappropriate antidiuretic hormone (SIADH) and heart failure, however these agents should be avoided in patients with cirrhosis.[2]

Interactions

Arginine vasopressin receptor 2 has been shown to interact with C1QTNF1.[3]

References

  1. ^ van den Ouweland AM, Knoop MT, Knoers VV, Markslag PW, Rocchi M, Warren ST, Ropers HH, Fahrenholz F, Monnens LA, van Oost BA (1992). "Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region". Genomics 13 (4): 1350–2.  
  2. ^ http://www.samsca.com/documents/pdf/prescribing-information-samsca.pdf
  3. ^ Innamorati, Giulio; Whang Michael Insuk; Molteni Raffaella; Le Gouill Christian; Birnbaumer Mariel (Nov 2002). "GIP, a G-protein-coupled receptor interacting protein". Regul. Pept. (Netherlands) 109 (1–3): 173–9.  

Further reading

  • Birnbaumer M (2001). "The V2 vasopressin receptor mutations and fluid homeostasis". Cardiovasc. Res. 51 (3): 409–15.  
  • Ishikawa SE (2002). "[Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2]". Nippon Rinsho 60 (2): 350–5.  
  • Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). "Molecular pharmacology and modeling of vasopressin receptors". Prog. Brain Res. 139: 179–96.  
  • Bichet DG (2006). "Nephrogenic diabetes insipidus". Advances in chronic kidney disease 13 (2): 96–104.  
  • Robben JH, Knoers NV, Deen PM (2006). "Cell biological aspects of the vasopressin type-2 receptor and  
  • Pan Y, Metzenberg A, Das S, et al. (1993). "Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus". Nat. Genet. 2 (2): 103–6.  
  • van den Ouweland AM, Dreesen JC, Verdijk M, et al. (1993). "Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus". Nat. Genet. 2 (2): 99–102.  
  • van den Ouweland AM, Knoop MT, Knoers VV, et al. (1992). "Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region". Genomics 13 (4): 1350–2.  
  • Rosenthal W, Seibold A, Antaramian A, et al. (1992). "Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus". Nature 359 (6392): 233–5.  
  • Seibold A, Brabet P, Rosenthal W, Birnbaumer M (1992). "Structure and chromosomal localization of the human antidiuretic hormone receptor gene". Am. J. Hum. Genet. 51 (5): 1078–83.  
  • Birnbaumer M, Seibold A, Gilbert S, et al. (1992). "Molecular cloning of the receptor for human antidiuretic hormone". Nature 357 (6376): 333–5.  
  • Lolait SJ, O'Carroll AM, McBride OW, et al. (1992). "Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus". Nature 357 (6376): 336–9.  
  • Knoers N, van der Heyden H, van Oost BA, et al. (1989). "Three-point linkage analysis using multiple DNA polymorphic markers in families with X-linked nephrogenic diabetes insipidus". Genomics 4 (3): 434–7.  
  • Tsukaguchi H, Matsubara H, Taketani S, et al. (1995). "Binding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidus". J. Clin. Invest. 96 (4): 2043–50.  
  • Faà V, Ventruto ML, Loche S, et al. (1995). "Mutations in the vasopressin V2-receptor gene in three families of Italian descent with nephrogenic diabetes insipidus". Hum. Mol. Genet. 3 (9): 1685–6.  
  • Birnbaumer M, Gilbert S, Rosenthal W (1995). "An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system". Mol. Endocrinol. 8 (7): 886–94.  
  • Wenkert D, Merendino JJ, Shenker A, et al. (1995). "Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus". Hum. Mol. Genet. 3 (8): 1429–30.  
  • Oksche A, Dickson J, Schülein R, et al. (1995). "Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus". Biochem. Biophys. Res. Commun. 205 (1): 552–7.  
  • Bichet DG, Birnbaumer M, Lonergan M, et al. (1994). "Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus". Am. J. Hum. Genet. 55 (2): 278–86.  
  • Yuasa H, Ito M, Oiso Y, et al. (1994). "Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus". J. Clin. Endocrinol. Metab. 79 (2): 361–5.  

External links

  • GeneReviews/NCBI/NIH/UW entry on Nephrogenic Diabetes Insipidus
  • "Symbol Report: AVPR2". Human Geneome Organization Gene Nomenclature Committee. 
  • "2"Vasopressin and Oxytocin Receptors: V. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
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