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Autoimmune polyendocrine syndrome type 2

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Title: Autoimmune polyendocrine syndrome type 2  
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Subject: Adrenal insufficiency, Autoimmune polyendocrine syndrome
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Autoimmune polyendocrine syndrome type 2

Autoimmune polyendocrine syndrome type 2
Classification and external resources
ICD-10 9 OMIM DiseasesDB eMedicine MeSH D016884

Autoimmune polyendocrine syndrome type 2, a form of autoimmune polyendocrine syndrome also known as Schmidt's syndrome,[1] or APS-II, is the most common form of the polyglandular failure syndromes.[2] It is more heterogeneous and has not been linked to one gene. Rather, patients are at a higher risk when they carry a particular human leukocyte antigen genotype (DQ2, DQ8 and DRB1*0404). APS-II affects women to a greater degree than men (75% of cases occur in women).[2]

Features of this syndrome are:

Less common associations include hypogonadism and vitiligo.


Symptoms of Addison's disease and Hashimoto's thyroiditis include:

  • Dry hair
  • Nausea
  • Abdominal Pain
  • Frequent urination
  • Vomiting
  • Weight and muscle loss
  • Salt cravings / salt wasting
  • Anorexia and cachexia
  • High pulse / weakened heart
  • Low blood pressure
  • Weakness
  • Hypoglycemia
  • Numbness in extremities
  • Migraines / dysparunia
  • Poor immune system response

Some researchers favour splitting this syndrome into three distinct syndromes (numbering 2, 3[4] and 4), but research evidence for these distinct combinations is not convincing.


It is named for Hermann Adolf Alexander Schmidt (1831 – 1894), an Estonian / Baltic-German Physiologist.


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