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Title: Azastene  
Author: World Heritage Encyclopedia
Language: English
Subject: Cyanoketone, Cyproterone acetate, Metyrapone, 22R-Hydroxycholesterol, 20α,22R-Dihydroxycholesterol
Collection: Isoxazoles, Steroids
Publisher: World Heritage Encyclopedia


Other names
Jmol-3D images Image
Molar mass 355.52 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Azastene is a chemical that modulates 3β-hydroxysteroid dehydrogenase activity.[1]


Azastene synthesis:[2]

One synthesis of this compound involves initial alkylation of methyl testosterone by means of strong base and methyl iodide to afford the 4,4-dimethyl derivative. Formylation with alkoxide and methyl formate leads to the 2-hydroxymethyl derivative. Reaction of this last with hydroxylamine leads to formation of an isoxazole ring. There is then obtained azastene.


  1. ^
  2. ^ Gordon O. Potts, Sterling Drug Inc. U.S. Patent 3,966,926 (1976).
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