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Bhf-177

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Title: Bhf-177  
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Subject: N4-Chloroacetylcytosine arabinoside, GABA transaminase inhibitor, (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid, Gabaculine, GABA receptor antagonist
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Bhf-177

BHF-177
Systematic (IUPAC) name
N-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-yl]-2-methyl-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinamine
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
ChemSpider  YesY
Chemical data
Formula C19H20F3N3 
Mol. mass 347.377 g/mol
 YesY   

BHF-177 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It was shown to reduce self-administration of nicotine in animal studies.[2]

References

  1. ^ Guery, S; Floersheim, P; Kaupmann, K; Froestl, W (2007). "Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors". Bioorganic & Medicinal Chemistry Letters 17 (22): 6206–11.  
  2. ^ Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A (2008). "Positive Modulation of GABAB Receptors Decreased Nicotine Self-administration and Counteracted Nicotine-induced Enhancement of Brain Reward Function in Rats". J. Pharmacol. Exp. Ther. 326 (1): 306–14.  


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