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BSPP (drug)

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Title: BSPP (drug)  
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Subject: N4-Chloroacetylcytosine arabinoside, GABA transaminase inhibitor, (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid, Phaclofen, Gabaculine
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BSPP (drug)

BSPP (drug)
Systematic (IUPAC) name
2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol
Clinical data
Legal status
?
Identifiers
ATC code None
PubChem
ChemSpider
Chemical data
Formula C21H34O2 
Mol. mass 318.492 g/mol
 YesY   

BSPP is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It has a synergistic effect with GABAB agonists such as baclofen at GABAB autoreceptors but not heteroreceptors, suggesting it may be useful for distinguishing between these GABAB receptor subtypes.[2]

References

  1. ^ Kerr DIB, Khalafy J, Ong J, Perkins MV, Prager RH, Puspawati NM, Rimaz M. Synthesis and Biological Activity of Allosteric Modulators of GABAB Receptors, Part 2. 3-(2,6-Bis-tert-butyl-4-hydroxyphenyl)propanols. Australian Journal of Chemistry. 2006;59:457-462.
  2. ^ Parker DA, Marino V, Ong J, Puspawati NM, Prager RH. The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors. Clinical and Experimental Pharmacology and Physiology. 2008 Sep;35(9):1113-5. PMID 18430050


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