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Cd137

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Title: Cd137  
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Subject: CXCR6, Tumor necrosis factor receptor, IL3RA, C-C chemokine receptor type 7, CCR8 (gene)
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Cd137

Tumor necrosis factor receptor superfamily, member 9
Identifiers
Symbols  ; 4-1BB; CD137; CDw137; ILA
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA).

Expression

CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.

Specific effects on cells

The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.

See also

Interactions

CD137 has been shown to interact with TRAF2.[1][2]

References

  1. ^ Jang, I K; Lee Z H; Kim Y J; Kim S H; Kwon B S (Jan 1998). "Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B". Biochem. Biophys. Res. Commun. (UNITED STATES) 242 (3): 613–20.  
  2. ^ Arch, R H; Thompson C B (Jan 1998). "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB". Mol. Cell. Biol. (UNITED STATES) 18 (1): 558–65.  

Further reading

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