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Cd138

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Cd138

Syndecan 1
Available structures
PDB Ortholog search: RCSB
Identifiers
SDC1 Gene
RNA expression pattern

Syndecan 1 is a protein which in humans is encoded by the SDC1 gene.[1][2]

Function

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.[3]

Application

It is a useful marker for plasma cells,[4] but only if the cells tested are already known to be derived from blood.[5]

References

Further reading

External links

  • Medical Subject Headings (MeSH)


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