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Cd70

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Title: Cd70  
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Subject: Tumor necrosis factors, CD43, B-cell activating factor, Clusters of differentiation, CD164
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Cd70

CD70 molecule
Identifiers
Symbol CD70
Alt. symbols CD27LG, TNFSF7
Entrez 970
HUGO 11937
OMIM 602840
RefSeq NM_001252
UniProt P32970
Other data
Locus Chr. 19 p13

CD70 (Cluster of Differentiation 70) is a ligand for CD27.

Contents

  • Clinical significance 1
  • Drug development 2
  • See also 3
  • References 4
  • External links 5

Clinical significance

The CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas). It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes do not express a lot of CD70.[1]

Drug development

ARGX-110 is a CD70-specific antibody that is currently under investigation for the treatment of hematological malignancies. It is being developed by the Belgian company arGEN-X. In December 2013 a first part of a phase 1b trial was completed. In January 2014 a safety and efficacy phase of the study started.[2]

Vorsetuzumab mafodotin is a CD70-targeted antibody-drug conjugate that started clinical trials for renal cell carcinoma.[3]

See also

References

  1. ^ Israel BF, Gulley M, Elmore S, Ferrini S, Feng WH, Kenney SC (2005). "Anti-CD70 antibodies: a potential treatment for EBV+ CD70-expressing lymphomas". Mol. Cancer Ther. 4 (12): 2037–44.  
  2. ^ "ARGX-110: first-in-class CD70-targeting antibody with unique mode of therapeutic action". arGEN-X. Retrieved 28 February 2015. 
  3. ^ Seattle Genetics Third Quarter 2013 Financial Report

External links


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