World Library  
Flag as Inappropriate
Email this Article

Cdk9

Article Id: WHEBN0009434461
Reproduction Date:

Title: Cdk9  
Author: World Heritage Encyclopedia
Language: English
Subject: MCEF, P-TEFb
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Cdk9

Cyclin-dependent kinase 9
1PF6.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.11.22, 2.7.11.23
RNA expression pattern

Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.[1] CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle.[2]

Interactions

CDK9 has been shown to interact with Cyclin K,[3] Cyclin T2,[4] RELA,[5] Cyclin T1,[3][4][6][7][8][9][10][11][12] Retinoblastoma protein,[13] Androgen receptor,[14] SKP1A,[10] MYBL2,[11] CDC34[10] and SUPT5H.[12]

References

Further reading

External links

  • Medical Subject Headings (MeSH)
  • - The Interactive Fly


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.