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Celsr2

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Subject: Cadherin, Laminin, Flamingo (protein), Mir-96 microRNA
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Celsr2

Cadherin, EGF LAG seven-pass G-type receptor 2
Identifiers
CELSR2 Gene
RNA expression pattern

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.[1][2]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[2]

See also

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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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