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Cxcl1

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Cxcl1

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

PDB rendering based on 1mgs.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene.[1]

Function

CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis.[2][3] CXCL1 is expressed by macrophages, neutrophils and epithelial cells,[4][5] and has neutrophil chemoattractant activity.[6][7] CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.[8][9][10][11] This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.[8] The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines.[12] An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.[13]

References

  1. ^ Haskill S, Peace A, Morris J, Sporn SA, Anisowicz A, Lee SW, Smith T, Martin G, Ralph P, Sager R (October 1990). "Identification of three related human GRO genes encoding cytokine functions". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7732–6.  
  2. ^ Anisowicz A, Bardwell L, Sager R (October 1987). "Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells". Proc. Natl. Acad. Sci. U.S.A. 84 (20): 7188–92.  
  3. ^ Richmond A, Thomas HG (February 1988). "Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution". J. Cell. Biochem. 36 (2): 185–98.  
  4. ^ Iida N, Grotendorst GR (October 1990). "Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue". Mol. Cell. Biol. 10 (10): 5596–9.  
  5. ^ Becker S, Quay J, Koren HS, Haskill JS (March 1994). "Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages". Am. J. Physiol. 266 (3 Pt 1): L278–86.  
  6. ^ Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M (May 1990). "Neutrophil-activating properties of the melanoma growth-stimulatory activity". J. Exp. Med. 171 (5): 1797–802.  
  7. ^ Schumacher C, Clark-Lewis I, Baggiolini M, Moser B (November 1992). "High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils". Proc. Natl. Acad. Sci. U.S.A. 89 (21): 10542–6.  
  8. ^ a b Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, Ransohoff RM, Miller RH (August 2002). "The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration". Cell 110 (3): 373–83.  
  9. ^ Devalaraja RM, Nanney LB, Du J, Qian Q, Yu Y, Devalaraja MN, Richmond A (August 2000). "Delayed wound healing in CXCR2 knockout mice". J. Invest. Dermatol. 115 (2): 234–44.  
  10. ^ Haghnegahdar H, Du J, Wang D, Strieter RM, Burdick MD, Nanney LB, Cardwell N, Luan J, Shattuck-Brandt R, Richmond A (January 2000). "The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma". J. Leukoc. Biol. 67 (1): 53–62.  
  11. ^ Owen JD, Strieter R, Burdick M, Haghnegahdar H, Nanney L, Shattuck-Brandt R, Richmond A (September 1997). "Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins". Int. J. Cancer 73 (1): 94–103.  
  12. ^ Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R (July 1988). "Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin". EMBO J. 7 (7): 2025–33.  
  13. ^ Omari KM, Lutz SE, Santambrogio L,  
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