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Chitin

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Title: Chitin  
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Subject: Cell wall, Chitin nanofibril, Radula, Carbohydrate, Mineralized tissues
Collection: Acetamides, Biomolecules, Biopesticides, Polysaccharides
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Chitin

Structure of the chitin molecule, showing two of the N-acetylglucosamine units that repeat to form long chains in β-1,4 linkage.
A close-up of the wing of a sap beetle; the wing is composed of chitin.

Chitin (thin-film interference: similar, analogous structures made of keratin are found in iridescent bird plumage.[1]

Contents

  • Etymology 1
  • Chemistry, physical properties and biological function 2
  • Fossil record 3
  • Uses 4
    • Agriculture 4.1
    • Industrial 4.2
    • Medicine 4.3
    • Biomedical research 4.4
  • See also 5
  • References 6
  • External links 7

Etymology

The English word "chitin" comes from the French word chitine, which first appeared in 1821 and derived from the Greek word χιτών (chiton), meaning covering.[2]

A similar word, "chiton", refers to a marine animal with a protective shell (also known as a "sea cradle").

Chemistry, physical properties and biological function

The structure of chitin was solved by Albert Hofmann in 1929.[3]

Chitin is a modified polysaccharide that contains nitrogen; it is synthesized from units of N-acetylglucosamine (to be precise, 2-(acetylamino)-2-deoxy-D-glucose). These units form covalent β-1,4 linkages (similar to the linkages between glucose units forming cellulose). Therefore, chitin may be described as cellulose with one hydroxyl group on each monomer replaced with an acetyl amine group. This allows for increased hydrogen bonding between adjacent polymers, giving the chitin-polymer matrix increased strength.

A cicada emerges from its chitinous larval exoskeleton.

In its pure, unmodified form, chitin is translucent, pliable, resilient, and quite tough. In most arthropods, however, it is often modified, occurring largely as a component of composite materials, such as in sclerotin, a tanned proteinaceous matrix, which forms much of the exoskeleton of insects. Combined with calcium carbonate, as in the shells of crustaceans and molluscs, chitin produces a much stronger composite. This composite material is much harder and stiffer than pure chitin, and is tougher and less brittle than pure calcium carbonate.[4] Another difference between pure and composite forms can be seen by comparing the flexible body wall of a caterpillar (mainly chitin) to the stiff, light elytron of a beetle (containing a large proportion of sclerotin).[5]

Scarab beetles in the genus Cyphochilus demonstrate an exceptional form of chitin in the white scales covering their bodies, as they are whiter than paper or any artificial material produced so far. What makes these scales so white is the special arrangement of the chitin elements inside them, together with their varied shapes and sizes; the chitin filaments are just a few millionths of a metre thick, and tightly packed, scattering light efficiently, deflecting all colours with equal strength, but still able keep a degree of disorder in their shape.[6] In addition, some social wasps species, such as Protopolybia chartergoides, orally secrete material containing predominantly chitin to build envelopes for their nests.[7]

Fossil record

Chitin was probably present in the exoskeletons of Cambrian arthropods such as trilobites. The oldest preserved chitin dates to the Oligocene, about , comprising a scorpion encased in amber.[8]

Uses

Agriculture

Most recent studies point out that chitin is a good inducer of defense mechanisms in plants.[9] It has also been assessed as a fertilizer that can improve overall crop yields.[10] The EPA regulates chitin for agricultural use within the USA.[11] Chitosan is prepared from chitin by deacetylation.

Industrial

Chitin is used in industry in many processes. Examples of the potential uses of chemically modified chitin in food processing include the formation edible films and as an additive to thicken and stabilize foods[12] and pharmaceuticals. It also acts as a binder in dyes, fabrics, and adhesives. Industrial separation membranes and ion-exchange media can be made from chitin. Processes to size and strengthen paper employ chitin and chitosan.[13][14] Researchers have developed a method for using chitosan as a reproducible form of biodegradable plastic[15] and as a promising substrate for engineering human tissues by use of three-dimensional bioprinting.[16]

Medicine

Chitin's flexibility and strength make it favorable as surgical thread. Its biodegradibility means it wears away with time as the wound heals. Moreover, chitin has been reported to have some unusual properties that accelerate healing of wounds in humans.[17][18][19] Occupations associated with high environmental chitin levels, such as shellfish processors, are prone to high incidences of asthma. Recent studies have suggested that chitin may play a role in a possible pathway in human allergic disease. To be specific, mice treated with chitin develop an allergic response, characterized by a build-up of interleukin-4-expressing innate immune cells. In these treated mice, additional treatment with a chitinase enzyme abolishes the response.[20]

Biomedical research

Chitin may be employed for affinity purification of recombinant protein. A chitin binding moiety is genetically fused to a protein of interest and then connected to beads coated with chitin. The immobilized protein is purified and released from the beads by cleaving off the chitin binding moiety.

See also

References

  1. ^
  2. ^ Auguste Odier (presented: 1821 ; published: 1823) "Mémoire sur la composition chimique des parties cornées des insectes" (Memoir on the chemical composition of the horny parts of insects), Mémoires de la Société d'Histoire Naturelle de Paris, 1 : 29-42. From page 35: "… la Chitine (c'est ainsi que je nomme cette substance de chiton, χιτον, enveloppe) …" (… chitine (it is thus that I name this substance from chiton, χιτον, covering) …)
  3. ^ Hofmann hydrolyzed chitin using a crude preparation of the enzyme chitinase, which he obtained from the snail Helix pomatia. See:
    • A. Hofmann (1929) "Über den enzymatischen Abbau des Chitins und Chitosans" (On the enzymatic degradation of chitin and chitosan), Ph.D. thesis, University of Zurich (Zurich, Switzerland).
    • P. Karrer and A. Hofmann (1929) "Polysaccharide XXXIX. Über den enzymatischen Abbau von Chitin and Chitosan I," Helvetica Chimica Acta, 12 (1) : 616-637.
    • Nathaniel S. Finney and Jay S. Siegel (2008) "In Memorian: Albert Hofmann (1906-2008)," Chimia, 62 (5) : 444-447 ; see page 444. Available on-line at: University of Zurich
  4. ^ Campbell, N. A. (1996) Biology (4th edition) Benjamin Cummings, New Work. p.69 ISBN 0-8053-1957-3
  5. ^
  6. ^
  7. ^ Kudô, K. Nest materials and some chemical characteristics of nests of a New World swarm-founding polistine wasp, (Hymenoptera Vespidae). Ethology, ecology & evolution 13.4 Oct 2001: 351-360. Dipartimento di biologia animale e genetica, Università di Firenze. 16 Oct 2014.
  8. ^
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  10. ^ Chitosan#Agricultural .26 Horticultural use
  11. ^
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External links

  • Horseshoe Crab Chitin Research
  • Information about Chitin (Heppe Medical Chitosan)
  • Chitin at the US National Library of Medicine Medical Subject Headings (MeSH)
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