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Chlorisondamine

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Title: Chlorisondamine  
Author: World Heritage Encyclopedia
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Subject: Ganglionic blocker, Quaternary ammonium compounds, Cholinergics, WIN-2299, Butinoline
Collection: Chloroarenes, Organochlorides, Quaternary Ammonium Compounds
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Chlorisondamine

Chlorisondamine
Systematic (IUPAC) name
trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-isoindolin-2-ium-2-yl)ethyl]ammonium dichloride
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
PubChem
ChemSpider  YesY
UNII  YesY
ChEMBL
Chemical data
Formula C14H20Cl6N2 
Mol. mass 429.04 g/mol
 YesY   

Chlorisondamine is a nicotinic acetylcholine receptor antagonist that produces both neuronal and ganglionic blockade.

Chlorisondamine has been shown to form noncovalent complexes with various biomolecules including sphingomyelin and other associated glycolipids.[1][2][3]

References

  1. ^ Woods, A. S.; Moyer, S. C.; Wang, H. Y. J.; Wise, R. A., "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor". Journal of Proteome Research 2003, 2 (2), 207–212.
  2. ^ Jackson, S. N.; Wang, H. Y. J.; Woods, A. S., "Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS". Journal of the American Society for Mass Spectrometry 2005, 16 (2), 133–138.
  3. ^ Woods, A. S.; Ugarov, M.; Egan, T.; Koomen, J.; Gillig, K. J.; Fuhrer, K.; Gonin, M.; Schultz, J. A., "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS". Analytical Chemistry 2004, 76 (8), 2187–2195.



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