World Library  
Flag as Inappropriate
Email this Article

Corticotropin releasing hormone receptor 1

Article Id: WHEBN0014145348
Reproduction Date:

Title: Corticotropin releasing hormone receptor 1  
Author: World Heritage Encyclopedia
Language: English
Subject: Corticotropin-releasing hormone, HEK 293 cells, Urocortin, Small nucleolar RNA SNORD115, List of human hormones
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Corticotropin releasing hormone receptor 1

Corticotropin releasing hormone receptor 1
3EHS.
Available structures
PDB Ortholog search: RCSB
Identifiers
CRHR1 Gene
RNA expression pattern

Corticotropin releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name.[1] In humans, CRF1 is encoded by the CRHR1 gene.[2][3]

Function

The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.[4]

CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.[5]

Clinical significance

Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroid therapy in asthma.[6]

CRF1 triggers cells to release hormones that are linked to stress and anxiety.[7] Hence CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.[8][9]

Interactions

Corticotropin releasing hormone receptor 1 has been shown to interact with Corticotropin-releasing hormone[10][11] and Urocortin.[12]

See also

References


Further reading

External links

  • Medical Subject Headings (MeSH)
  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.